Results 81 to 90 of about 374,565 (262)

Environmental Indicators

, 1992
The report discusses possible logical structures and content of a set of environmental indicators for Norway. The emphasis is on structure; proposals for specific indicators and data presented are of a more preliminary nature.
Alfsen, Knut H., Brekke, Kjell Arne, Brunvoll, Frode, Lurås, Hilde, Nyborg, Karine   +4 more
openaire   +3 more sources

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Heavy metals on honeybees indicate their concentration in the atmosphere. a proof of concept

Italian Journal of Animal Science, 2019
The aim of this research was to evaluate as a proof of concept, a quantitative relationship between atmospheric particulate matter (PM10), atmospheric heavy metals (Pb, Ni and Cd) and Pb, Ni and Cd concentrations accumulated on bees reared in a beehive ...
Annamaria Costa, Mauro Veca, Maurizio Barberis, Alessandra Tosti, Giacomo Notaro, Stefano Nava, Massimo Lazzari, Alessandro Agazzi, Francesco Maria Tangorra   +8 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Quantitative analysis of dust pollution characteristics and influencing factors in mining areas based on statistical modelling

矿业科学学报
As disorderly dust emission of open-pit mines often leads to ecological degradation, this study therefore conducts a quantitative analysis on the evolution patterns of particle changes and the influence of environmental indicators on the weights of ...
ZHAO Hongbao, ZHAI Rupeng, GE Haibin, CHEN Chaonan, LIU Shaoqiang, JING Shijie   +5 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Multi-Task Classification for Improved Health Outcome Prediction Based on Environmental Indicators. [PDF]

IEEE Access, 2023
Alirezaei M, Nguyen QC, Whitaker R, Tasdizen T.   +3 more
europepmc   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source