Results 81 to 90 of about 373,186 (262)

Research of energy efficiency indicators of a hybrid electric automotive power unit based on a spark ignition engine

Вісник Національного транспортного університету
The article examined the results of an experimental study on the energy-efficiency indicators of a hybrid electric automotive power unit based on a spark-ignition engine.
M. Tsiuman, I. Sadovnyk
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Geosalud: relaciones geográficas entre salud y ambiente Geohealth: geographic relations between health and environment

Revista Cubana de Higiene y Epidemiología, 2004
En respuesta a los intereses del PNUMA y la OPS, se hace necesario incorporar el componente salud dentro de las prioridades del proyecto GEO, que hasta el momento solo ha logrado representar el comportamiento de los problemas ambientales a nivel mundial ...
Dianelis Pérez Jiménez, Pedro Más Bermejo, Vicente Prieto Díaz, Miriam Rodríguez González <a name=autor></a>   +3 more
doaj  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Monitoring boreal avian populations: how can we estimate trends and trajectories from noisy data?

Avian Conservation and Ecology, 2019
Substantial effort has been dedicated to developing reliable monitoring schemes for North American bird populations, but our ability to monitor bird populations in the boreal forest remains limited because of the sparsity of long-term data sets ...
Christian Roy, Nicole L. Michel, Colleen M. Handel, Steven L. Van Wilgenburg, J. Curtis. Burkhalter, Kirsty E. B. Gurney, David J. Messmer, Karine Princé, Clark S. Rushing, James F. Saracco, Richard Schuster, Adam C. Smith, Paul A. Smith, Péter Sólymos, Lisa A. Venier, Ben Zuckerberg   +15 more
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Multi-Task Classification for Improved Health Outcome Prediction Based on Environmental Indicators. [PDF]

IEEE Access, 2023
Alirezaei M, Nguyen QC, Whitaker R, Tasdizen T.   +3 more
europepmc   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source