Results 61 to 70 of about 374,565 (262)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Non-Financial Reporting and Reporting for Management in the Circumstances of the Coronavirus Crisis

CECCAR Business Review, 2020
The modern world and all the economies worldwide are closely interlocked. The effects of any event occurring in any part of the world can impact the entire world.
Daniela Artemisa CALU, Mirela NICHITA
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Uso de opalas biogênicas na identificação de sedimentos lacustres e marinhos Biogenic opals in the identification of lacustrine and marine sediments

Revista Brasileira de Ciência do Solo, 2007
Procurou-se utilizar opalas biogênicas, também conhecidas como espículas ou "pó-de-mico", como identificadoras de sedimentos lacustres ou marinhos. Para isso, analisaram-se camadas e horizontes de um Gleissolo Tiomórfico Húmico na região do rio Riacho ...
João Luiz Lani, Larry Schwandes, Sérvulo Batista de Rezende, José Antonio Lani, Eufran Ferreira do Amaral, Alexson de Mello Cunha, Liovando Marciano da Costa   +6 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Aligning rural credit with sustainable practices: environmental indicators for agricultural policies

Frontiers in Sustainable Food Systems
This study examines the interface between rural credit policies and environmental sustainability objectives in Brazil, focusing on the 2023/2024 Harvest Plan and the 2024–2027 Pluriannual Plan (PPA). The analysis reveals that, despite normative advances,
Luis Eduardo Pacifici Rangel, Luis Eduardo Pacifici Rangel, Eduardo Mello Mazzoleni, Marcelo Fernandes Guimarães, Bruno dos Santos Alves Figueiredo Brasil, Bruno dos Santos Alves Figueiredo Brasil, Jorge Madeira Nogueira, Ricardo Carmona   +7 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

EXPERT SYSTEMS FOR ENVIRONMENTAL PROTECTION IN MINING

Rudarsko-geološko-naftni Zbornik, 2012
Expert systems are used in various activities with the main goal of decision-making in intelligent and transparent way. In business decision-making, such systems are directed to pure operational and economical decisions.
Damir Rumenjak
doaj  

Characteristics of travertine profiles and their environmental indications in Munigou, Sichuan, China

Carsologica Sinica
The travertine profiles are located in the Zhaga waterfall in Munigou, Sichuan Province, where the highest altitude ranges from 4,070 m to 2,800 m, and the average annual temperature is 7℃.
Jingwen HE, Qunwei DAI, Ronglin XU, Jie CUI, Dejun AN, Weiqi DU, Ting ZHANG, Ruiyang JIANG, Yue RAN   +8 more
doaj   +1 more source