Results 141 to 150 of about 2,842,568 (349)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Arbuscular mycorrhizal fungi and Streptomyces: brothers in arms to shape the structure and function of the hyphosphere microbiome in the early stage of interaction

Microbiome
Background Fungi and bacteria coexist in a wide variety of environments, and their interactions are now recognized as the norm in most agroecosystems.
Zexing Jin, Feiyan Jiang, Letian Wang, Stéphane Declerck, Gu Feng, Lin Zhang   +5 more
doaj   +1 more source

Caribou data from Disentangling social interactions and environmental drivers in multi-individual wildlife tracking data

, 2018
Justin M. Calabrese, Chris H. Fleming, William F. Fagan, Martin Rimmler, Petra Kaczensky, Sharon Bewick, Peter Leimgruber, Thomas Mueller   +7 more
openalex   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

A review of microbial-environmental interactions recorded in Proterozoic carbonate-hosted chert. [PDF]

Geobiology, 2023
Moore KR, Daye M, Gong J, Williford K, Konhauser K, Bosak T.   +5 more
europepmc   +1 more source

Interaction of environmental chemicals with the estrogen and progesterone receptors from the oviduct of the American alligator.

, 1996
Peter M. Vonier, D. Andrew Crain, John A. McLachlan, Louis J. Guillette, Steven F. Arnold   +4 more
openalex   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Plant DNA Methylation: An Epigenetic Mark in Development, Environmental Interactions, and Evolution. [PDF]

Int J Mol Sci, 2022
Lucibelli F, Valoroso MC, Aceto S.
europepmc   +1 more source

Voluntary Emission Reductions, Social Rewards, and Environmental Policy [PDF]

Social norms and intrinsic motivations lead to environmentally friendly behaviour even in the absence of environmental policy. This paper looks at the interactions of social norms and environmental regulation in their impact on individual behaviour ...
Michael Rauscher
core  

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source