Results 51 to 60 of about 940,200 (260)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

AhNRAMP1 Enhances Manganese and Zinc Uptake in Plants

Frontiers in Plant Science, 2019
Manganese (Mn) and zinc (Zn) play essential roles in plants. Members of the natural resistance-associated macrophage protein (NRAMP) family transport divalent metal ions.
Nanqi Wang, Wei Qiu, Jing Dai, Xiaotong Guo, Qiaofang Lu, Tianqi Wang, Shiqin Li, Tongtong Liu, Yuanmei Zuo   +8 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Genetic and environmental interaction in allergy and asthma☆☆☆ [PDF]

Journal of Allergy and Clinical Immunology, 1999
Asthma is an inflammatory disorder of the airways involving coordinate up-regulation of T(H)2-type cytokines encoded in a cluster on chromosome 5q(31-33) on T cells and inflammatory cells. There is also a requirement for local airway susceptibility factors that, together with T(H)2 polarization, results in hyperresponsiveness, variable airflow ...
openaire   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Drought-tolerant rhizobacterial consortia with diverse plant growth promoting traits enhance wheat and faba bean growth under water and low-P availability promising multi-traits

BMC Microbiology
Background Staple crops like wheat and faba bean are increasingly subjected to multiple and simultaneous stresses, resulting in substantial yield reduction.
Bouchra Benmrid, Mohamed Idbella, Giuliano Bonanomi, Said Khourchi, Mara Gherardelli, Adnane Bargaz, Ghoulam Cherki   +6 more
doaj   +1 more source

Responses of a native plant species from invaded and uninvaded areas to allelopathic effects of an invader

Ecology and Evolution, 2019
Invaders exert new selection pressures on the resident species, for example, through competition for resources or by using novel weapons. It has been shown that novel weapons aid invasion but it is unclear whether native species co‐occurring with ...
Anne Lyytinen, Leena Lindström
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Long-term genomic coevolution of host-parasite interaction in the natural environment

Nature Communications, 2017
Arms races between phage and bacteria are well known from lab experiments, but insight from field systems is limited. Here, the authors show changes in the resistance and CRISPR loci of bacteria and the infectivity, host range and genome size of phage ...
Elina Laanto, Ville Hoikkala, Janne Ravantti, Lotta-Riina Sundberg   +3 more
doaj   +1 more source

Virus-induced Gene Silencing (VIGS) in Barley Seedling Leaves

Bio-Protocol, 2015
Virus induced gene silencing (VIGS) is one of the most potent reverse genetics technologies for gene functional characterisation. This method exploits a dsRNA-mediated antiviral defence mechanism in plants.
Lokanadha Gunupuru, Shahin Ali, Fiona Doohan, Steven Scofield   +3 more
doaj   +1 more source