Results 81 to 90 of about 2,842,568 (349)
Genetic and environmental interaction in allergy and asthma☆☆☆ [PDF]
Journal of Allergy and Clinical Immunology, 1999 Asthma is an inflammatory disorder of the airways involving coordinate up-regulation of T(H)2-type cytokines encoded in a cluster on chromosome 5q(31-33) on T cells and inflammatory cells. There is also a requirement for local airway susceptibility factors that, together with T(H)2 polarization, results in hyperresponsiveness, variable airflow ...
openaire +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
mSystems, 2018 Mobile genetic elements such as conjugative plasmids are responsible for antibiotic resistance phenotypes in many bacterial pathogens. The ability to conjugate, the presence of antibiotics, and ecological interactions all have a notable role in the ...
Johannes Cairns +10 more
doaj +3 more sources
Long-term genomic coevolution of host-parasite interaction in the natural environment
Nature Communications, 2017 Arms races between phage and bacteria are well known from lab experiments, but insight from field systems is limited. Here, the authors show changes in the resistance and CRISPR loci of bacteria and the infectivity, host range and genome size of phage ...
Elina Laanto +3 more
doaj +1 more source
Environmental interactions in Space Exploration: Announcement of the formation of an Environmental Interactions Working Group [PDF]
With the advent of the Space Exploration Initiative, the possibility of designing and using systems on scales not heretofore attempted presents exciting new challenges in systems design and space science.
Hillard, G. Barry, Kolecki, Joseph C.
core +1 more source
Plant–plant interactions and environmental change [PDF]
New Phytologist, 2006 SummaryNatural systems are being subjected to unprecedented rates of change and unique pressures from a combination of anthropogenic environmental change drivers. Plant–plant interactions are an important part of the mechanisms governing the response of plant species and communities to these drivers.
openaire +3 more sources
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
EnviroNET: An online environmental interactions resource [PDF]
EnviroNET is a centralized depository for technical information on environmentally induced interactions likely to be encountered by spacecraft in both low-altitude and high-altitude orbits. It provides a user-friendly, menu-driven format on networks that
Lauriente, Michael
core +1 more source
Interferometric modulation of quantum cascade interactions
, 2018 We consider many-body quantum systems dissipatively coupled by a cascade network, i.e. a setup in which interactions are mediated by unidirectional environmental modes propagating through a linear optical interferometer.
Cusumano, Stefano +2 more
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source