Results 51 to 60 of about 1,386,369 (288)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Private Options to Use Public Goods: Exploiting Revealed Preferences to Estimate Environmental Benefits [PDF]

We develop and apply a new method for estimating the economic benefits of an environmental amenity. The method fits within the household production framework (Becker 1965), and is based upon the notion of estimating the derived demand for a privately ...
Snyder, Lori, Stavins, Robert, Wagner, Alexander   +2 more
core   +3 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Effectiveness of prior consultation on the environmental licensing process in the department of Chocó 2006-2011

Civilizar, 2014
The Department of Chocó is a “territory with an incalculable natural, ethnic and cultural wealth” (¿Qué es él Chocó Biogeográfico?, 2013); Prior consultation is a right and a mechanism involving ethnic groups, however, is not effective, or is an ...
Marisela Mena Valencia, Lisneider Hinestroza Cuesta   +1 more
doaj  

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

PEMBADANAN PRINSIP KEPEMERINTAHAN YANG BAIK (GOOD GOVERNANCE) DALAM PENERBITAN IZIN USAHA PERTAMBANGAN (IUP) (STUDI KASUS DI SULAWESI TENGGARA)

Perspektif Hukum, 2017
This work is aimed at exploring appropriate method in embodying and applying the principle of good governance in managing strategic resources, i.e in issuing mining license.
Oheo K. Haris
doaj   +1 more source

Can Previous Pro-Environmental Behaviours Influence Subsequent Environmental Behaviours? The Licensing Effect of Pro-Environmental Behaviours [PDF]

Journal of Pacific Rim Psychology, 2016
Methods for promoting individuals’ pro-environmental behaviours are becoming very important. Besides traditional factors relevant to pro-environmental actions, few studies have examined the licensing effect within this domain. Across three studies we have explored whether the licensing effect really exists in pro-environmental behaviours, how this ...
Liuna Geng, Xiao Cheng, Zhuxuan Tang, Kexin Zhou, Lijuan Ye   +4 more
openaire   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

PERANAN PEMERINTAH KOTA YOGYAKARTA DALAM MENINGKATKAN PELAYANAN PERIZINAN DAN MEWUJUDKAN FUNGSI IZIN SEBAGAI ALAT PENGENDALI BAGI KEGIATAN MASYARAKAT YANG MEMBAHAYAKAN LINGKUNGAN

Jurnal Media Hukum, 2015
The research aims to discover the relation between debureaucratization of licensing service and actualization of license function as a control to society’s threatening activities in order to avoid vicinity’s threats. The research resulted in some points,
Nurwigati Nurwigati
doaj