Results 51 to 60 of about 5,854,873 (289)

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Distribution of Virulence Genes in Clinical and Environmental Vibrio cholerae Strains in Bangladesh

, 2013
Vibrio cholerae, an environmental organism, is a facultative human pathogen. Here, we report the virulence profiles, comprising 18 genetic markers, of 102 clinical and 692 environmental V.
Choi J., Bradley Sack R., Grim C. J., Alam M., Colwella R. R., Siddique A., Huq A., Taviani E., Hasan N. A., Sadique A., Ceccarelli D., Abdus Sadique, R. Bradley Sack, Abul K. Siddique, Elisa Taviani, Munirul Alam, Rita R. Colwell, Jinna Choi, Nur A. Hasan, Christopher J. Grim, Anwar Huq, Daniela Ceccarelli   +21 more
core   +1 more source

Microbiome analysis in Asia’s largest watershed reveals inconsistent biogeographic pattern and microbial assembly mechanisms in river and lake systems

iScience
Summary: Microorganisms are critical to the stability of aquatic environments, and understanding the ecological mechanisms of microbial community is essential.
Xi Liu, Lu Zhang, Yingcai Wang, Sheng Hu, Jing Zhang, Xiaolong Huang, Ruiwen Li, Yuxin Hu, Huaiying Yao, Zhi Wang   +9 more
doaj   +1 more source

Application of a Database-Independent Approach To Assess the Quality of Operational Taxonomic Unit Picking Methods

mSystems, 2016
Assignment of 16S rRNA gene sequences to operational taxonomic units (OTUs) allows microbial ecologists to overcome the inconsistencies and biases within bacterial taxonomy and provides a strategy for clustering similar sequences that do not have ...
Patrick D. Schloss
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

BMT 302 - Environmental Microbiology [Mikrobiologi Persekitaran] [PDF]

, 2008
UNIVERSITI SAINS MALAYSIA Second Semester Examination Academic Session 2008/2009 April/May 2009 BMT 302 - Environmental Microbiology [Mikrobiologi Persekitaran] Duration: 3 hours [Masa : 3 ...
Pusat Pengajian Sains Kajihayat, PPSK
core   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Recognizing the Contribution of Data: The Use of Companion Articles To Highlight Novel Resources in Microbiology Research

mSystems, 2023
As part of society-wide efforts to promote open access in science, the American Society for Microbiology journals are piloting the publication of companion articles highlighting rigorous data resources.
Jack A. Gilbert, Irene L. G. Newton, Gemma Reguera   +2 more
doaj   +1 more source