Results 91 to 100 of about 5,439,350 (296)

Thermodynamic Analysis of the Solubility of Propylparaben in Acetonitrile–Water Cosolvent Mixtures

, 2023
Parabens are substances used in the food, pharmaceutical and cosmetic industries. Recent studies have indicated that these substances have toxic potential, cause endocrine disruption and can easily bioaccumulate; therefore, their physicochemical ...
Claudia Patricia Ortiz, Daniel Ricardo Delgado, Mauricio Herrera, Rossember Edén Cardenas-Torres   +3 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Environmental Sustainability in Practice

, 2017
1. Introduction: What is Environmental Sustainability?2. Sustainability Education3. Environmental Planning and Management4. Sustainable Agriculture5. Geospatial Technologies and Environmental Sustainability6.
Environmental Sustainability Research Centre
core   +1 more source

Predictive Environmental Risk Assessment of Chemical Mixtures: A Conceptual Framework

, 2012
Environmental risks of chemicals are still often assessed substance-by-substance, neglecting mixture effects. This may result in risk underestimations, as the typical exposure is toward multicomponent chemical "cocktails". We use the two well established
Backhaus, Thomas,, Faust, M.
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Innovative Applied Epidemiology Methods for Analysis of Environmental Mixtures

Environmental health professionals increasingly need tools to evaluate the health impacts of exposure to multiple environmental contaminants rather than individual pollutants.
Chris Gennings, Vishal Midya, Marianthi-Anna Kioumourtzoglou, Jennifer Bobb   +3 more
core   +1 more source

Acute toxicity of daphnia magna neonates exposed to single and composite mixtures of four emerging contaminants

, 2022
The effects of emerging contaminants on environmental health are of high concern, especially those potentially induced by mixtures. We assessed single and composite mixtures of triclosan (T), 17β-estradiol (E2), sulfamethoxazole (SMX), and nicotine (N ...
Perez Gonzalez, Bolivar Andres, Pinos Velez, Veronica Patricia, Araujo, Giuliana S., Tripaldi, Piercosimo, Cipriani Avila, Eva Isabel, Capparelli, Mariana V., Moulatlet, Gabriel M., Pinos-Vélez, Verónica, Pérez-González, Andrés, Cipriani-Ávila, Isabel, Araujo, Giuliana S. [UNESP]   +10 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

The Effect of Nopal Mucilage Addition on the Corrosion Rate of Reinforcement Steel in Concrete

Surfaces
Environmental humidity is a determining factor in the degradation of concrete structures, particularly in the corrosion process of reinforcement bars. This study analyzed four concrete mixtures with different mucilage contents replacing mixing water: 0 ...
Enrique Martínez-Barrios, UIises Páramo-García, Edgardo Jonathan Suárez-Domínguez, Josué Francisco Pérez-Sánchez   +3 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source