Results 81 to 90 of about 5,439,350 (296)

Case study of rutting performance of HMA modified with waste rubber powder

Case Studies in Construction Materials, 2014
Low resistance against dynamic loads and short service life of pavement are the most significant problems in the conservation and maintenance of roads, to the extent that, annually enormous costs are spent in order to improve capabilities of road ...
G.H. Shafabakhsh, M. Sadeghnejad, Y. Sajed   +2 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Effect of Crumb Rubber as Fine Aggregate Replacement in Cold Mixture Asphalt

Civil Engineering Dimension, 2019
The number of waste tires has been increasing as an impact of rapidly growing number of vehicles and becomes a global environmental concern. The environmental impact can be reduced by converting the waste tires to crumb rubber and reusing it as a ...
Paravita Sri Wulandari, Ken Kertorahardjo, Arianto Thesman, Daniel Tjandra   +3 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Statistical approaches to address multi-pollutant mixtures and multiple exposures: The State of the Science.

, 2017
PURPOSE OF REVIEW: The purpose of this review is to describe the most recent statistical approaches to estimate the effect of multi-pollutant mixtures or multiple correlated exposures on human health.
Basagaña, X., Stafoggia, M., Breitner, S., Hampel, R., Susanne Breitner, Regina Hampel, Hampel, R, Stafoggia, M, Breitner, S, Xavier Basagaña, Massimo Stafoggia, Basagaña, X   +11 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Techno-economic feasibility of CO2 utilization in sustainable energy harvesting: Energy–Exergy–Economic–Environmental (4E) analysis

Energy Conversion and Management: X
In the context of the green energy transition, the organic Rankine cycle (ORC) is explored for energy conversion from renewable energy sources. The majority of ORC systems are explored with synthetic chemicals-based zeotropic mixtures as working fluids ...
Kumaran Kannaiyan, Bhawandeep Sharma
doaj   +1 more source

Cellular and hormonal disruption of fetal testis development in sheep reared on pasture treated with sewage sludge [PDF]

, 2005
The purpose of this study was to evaluate whether experimental exposure of pregnant sheep to a mixture of environmental chemicals added to pasture as sewage sludge (n = 9 treated animals) exerted effects on fetal testis development or function ...
Paul, Catriona, Kyle, Carol E, McKinnell, Chris, Sharpe, Richard M, Catriona Paul, Richard M. Sharpe, Hayley Scott, Chris McKinnell, Scott, Hayley, Rhind, Stewart M, Carol E. Kyle, Stewart M. Rhind   +11 more
core   +1 more source