Results 91 to 100 of about 5,566,878 (300)
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Environmental indicators for the urban environment : a literature review [PDF]
, 2000 A vast body of literature exists on the genesis and evolution of environmental indicators of all varieties. This document attempts to track the somewhat complicated progress of urban environmental indicators, where they are in usage and to what avail. It
Convery, Frank J. +2 more
core +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Social movements in sustainability transitions : identity, social learning & power in the Spanish & Turkish water domains [PDF]
, 2010 Descripció del recurs: el 02 de novembre de 2010Dominant economic growth and nation-state building practices are often based on detaching individuals from other individuals and communities from their natural environment in which their livelihoods used to
Ilhan, Akgün +1 more
core +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Movimentos socioambientais e gestão dos recursos naturais no cenário amazônico: Ações da Confederação dos Povos Indígenas na Bolívia / Social environmental movements and management natural resources in the Amazon scenario: Action of indigenous confederation in Bolivia. [PDF]
Sociedade & Natureza, 2013 Provide inputs for the analysis of training and performance of environmental movements and rethink the ways of managing natural resources and conflicts arising that are in progress are justifications for this study. The aim is thus to offer both elements
Luciana Aparecida Iotti Ziglio +1 more
doaj
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Study of hourly truck movements around Atlanta
, 2002 Issued as final ...
Atlanta regional truck movements study +1 more
core
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source