Results 51 to 60 of about 5,791,975 (285)

Assessing the changing urban sound environment during the COVID-19 lockdown period using short-term acoustic measurements

open access: yesNoise Mapping, 2020
The implementation of lockdown measures due to the COVID-19 outbreak has resulted in wide-ranging social and environmental implications. Among the environmental impacts is a decrease in urban noise levels which has so far been observed at the city scale ...
Aletta Francesco   +4 more
doaj   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

open access: yesFEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Case Study of the Environmental Noise and its Perception in the City of Cluj-Napoca, Romania

open access: yesArchives of Acoustics, 2020
The noise perceiving issue is very subjective and depends on several factors, such as: the living environment in which each person has grown and developed, the education they have received, the culture in which their life principles have formed and, last
Diana Ioana POPESCU
doaj   +1 more source

Impact of road traffic noise on annoyance and preventable mortality in European cities: A health impact assessment

open access: yesEnvironment International, 2022
Background: Road traffic is the main source of environmental noise in European cities and one of the main environmental risks to health and wellbeing. In this study we aimed to provide an in-depth assessment of available road traffic noise data and to ...
Sasha Khomenko   +12 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Noise assessment of the small-scale wind farm [PDF]

open access: yesE3S Web of Conferences, 2019
The importance of renewable energy and especially of eolian systems is growing. For this reason, we propose the investigation of an important pollutant - the noise, which has become so important that European Commission and European Parliament introduced
Alionte Cristian-Gabriel   +1 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

People exposed to traffic noise in european agglomerations from noise maps. A critical review

open access: yesNoise Mapping, 2014
Two of the main objectives of the European Directive on environmental noise are, firstly, to unify acoustic indices for assessing environmental noise and, secondly, to standardize assessment methodologies.
Arana Miguel   +2 more
doaj   +1 more source

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