Results 71 to 80 of about 3,084,334 (312)
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Journal of Ecology and Environment, 2014 We estimated the influence of environmental factors on zooplankton communities at 25 reservoirs during winter (December 2010 to January 2011). Among zooplankton groups, Cyclops vicinus is more dominant during winter, and this is positively ...
Gea-Jae Joo +2 more
doaj +1 more source
Design strategies in facades for the reduction of housing energy consumption [PDF]
, 2010 This article analyzes the energy-saving potential of various facade design strategies from a life cycle perspective, including the energy needed in the use stage and the embodied energy of materials. The results provide reference data on the behaviour of
Alonso Ruiz-Rivas, Carmen +2 more
core +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Correlations between environmental parameters and nuclear activity [PDF]
The occurrence and quantitative properties of Seyfert 1 and Seyfert 2 galaxies as a function of the galaxy environment were studied in a systematic way.
Fricke, K. J., Kollatschny, W.
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Analysis of navigation pattern in the sport of rowing [PDF]
, 2012 The effect of weather and environmental conditions on sports has been extensively studied over the last few years (Pezzoli et al., 2010). Based upon the studies of Lobozewicz (1981) and of Kay and Vamplew (2002), Pezzoli and Cristofori (2008) have ...
Baldacci, A. +9 more
core
Ecological Life Cycle Assessment Modified Novolaks Waste Used in Industrial Wastewater Treatment [PDF]
, 2017 Ecological Life Cycle Assessment (LCA) applied in the assessment of the impact of products on the environment is a technique that allows for the evaluation of the environmental impact of polymeric flocculants used in industrial wastewater treatment ...
Bajdur, Wioletta M. +3 more
core +2 more sources
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Ecosphere, 2019 Type and intensity of land‐use vary in space and time and strongly contribute to changes in richness and composition of species communities. In this study, we examined land snail communities in forests and grasslands in three regions of Germany. We aimed
Katja Wehner +5 more
doaj +1 more source