Results 91 to 100 of about 314,285 (254)

CONSTRUCTION OF THE ENVIRONMENTAL PERFORMANCE INDEX USING DEA

Quantitative Methods in Economics, 2014
There is wide range of environmental performance indicators. The more sophisticated they are, the more arbitrary viewpoint they take. The EPI weights are established based on experts’ judgments form Yale University and Columbia University team.
Ewa Chodakowska
doaj  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Proposal of an environmental performance index to assess leather-manufacturing companies

Green Technologies and Sustainability
Despite the global economic and environmental importance of the leather industry, the specialized literature still presents an important gap in analyzing the environmental performance of the leather manufacturing process from the waste generated.
Marcelo Girotto Rebelato, Andréia Marize Rodrigues, Bruna Sousa Ferreira   +2 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Çevresel performans endeksi kapsamında Türkiye’de sürdürülebilir kalkınma: Çevresel ve kentsel göstergeler ışığında bir değerlendirme

Afyon Kocatepe Üniversitesi İktisadi ve İdari Bilimler Fakültesi Dergisi
Bu çalışmanın amacı Yale Üniversitesi tarafından yayımlanan Çevresel Performans Endeksi (EPI) kapsamında Türkiye’nin çevresel ve kentsel göstergeler bağlamında sürdürülebilir kalkınma düzeyinin değerlendirilmesidir.
Sadegül Durgun, Yeter Avşar
doaj  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Consumer Society, Environmental Performance Index And Evaluation of Environmental Performance For Turkey According To Environmental Performance Index

, 2012
Environmental Performance Index (EPI-Environmental Performance Index) is a major study which evaluates environmental health and ecosystem vitality of countries, two years apart. This study, prepared by Yale University and based on 16 performance indicators in 2006, 25 in 2008 and 2010, and finally 22 in 2012, evaluating the environmental performance ...
openaire   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source