Results 111 to 120 of about 314,285 (254)

The Effect of the Human Development Index on Environmental Performance Index Measurement: A Maqāṣid al-Sharī’ah Perspective

Al-Muamalat
This research aims to evaluate the improvement in the Human Development Index (HDI), which encompasses health, education, and income, between 2021 and 2023. Furthermore, this research analyses the relationship between the human development index and the
Prima Ariyo Widodo, Isman Isman, Risdayani Risdayani, Mamdukh Budiman   +3 more
doaj   +1 more source

Does Climate Policy Shape the Environmental Performance Index?

IOP Conference Series: Earth and Environmental Science
Abstract The study aims to identify the relationship between climate policy and environmental performance systematically. The methods used are bibliometric analysis with VOSviewer and Systematic Literature Review (SLR). This study analyzes peer-reviewed literature published in Scopus-indexed journals and published between 2015 and ...
Sepviana Nur Kumala, null Suryanto, null Sarjiyanto, Muh Hisjam, null Supriyono   +4 more
openaire   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Beyond Single-Dimension Metrics: Environmental Policy Performance Index and Its Implication for Environmental Governance in Europe

SAGE Open
This paper presents the Environmental Policy Performance Index (EPPI), a two-dimensional composite index designed to evaluate the effectiveness of environmental policy in a comprehensive and balanced way.
Tjaša Bartolj, Nika Murovec, Enia Bearzotti   +2 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Assessment of environmental challenges in Iran: Findings from the 2024 environmental performance index and expert opinions

آلودگی‌های محیطی و توسعه پایدار شهری
The Environmental Performance Index (EPI) is an essential tool for evaluating countries environmental performance, incorporating diverse criteria and data to assess both environment conditions and the impact of human activities.
Mohammad Mosaferi, Ziba Beheshti, Neda Gilani, Sepideh Nemati Mansour   +3 more
doaj  

Environmental Difficulty Index for Endurance Running Performance

This manuscript presents an Enviromental Difficulty Index (EDI), applicable to endurance running preformamce. This is a quantitative framework for adjusting running preformance based on ambient weather conditions. A review of existing literature was conducted to extract preformance penatlites per change of one unit of the applicable weather variable ...
openaire   +2 more sources