Results 141 to 150 of about 16,095,113 (285)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Incorporating Environmental Impacts in the Measurement of Agricultural Productivity Growth [PDF]

Agricultural production is known to have environmental impacts, both adverse and beneficial, and it is desirable to incorporate at least some of these impacts in an environmentally sensitive productivity index.
Lovell, C.A. Knox, Luu, H., Nehring, Richard F., Ball, V. Eldon   +3 more
core  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Environmental regulation and international trade patterns for agro-industrial under a South-North Perspective [PDF]

This paper aims at examining the relation between the international trade and the environment, particularly focused on sensitive agribusiness sectors. It consists on an empirical test to the conflicting positions supported by economists, some following ...
Feix, Rodrigo Daniel, Miranda, Silvia Helena Galvao de, Barros, Geraldo Sant'Ana de Camargo   +2 more
core  

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Potential Links Between Physiological and Perceptual Strain in High Heat Stress. [PDF]

Eur J Sport Sci
Zhao X, McDermott BP, Lo WJ.
europepmc   +1 more source

2024 Environmental Performance Index : Policymakers' summary

The purpose of the 2024 Environmental Performance Index – Policymakers’ Summary is to provide decision-makers with a concise overview of global environmental trends, comparative country performance, and key policy insights to guide actions toward ...
Sherbinin, Alex de, Wendling, Zachary A., Block, Sebastian, Emerson, John W.   +3 more
core  

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

A Diffusion-Based Digital Twin for Predicting Road Deterioration under Climate and Traffic Stress. [PDF]

Research (Wash D C)
Pan N, Du Y, Parlikad AK.
europepmc   +1 more source