Results 71 to 80 of about 57,018 (275)

PVNCRF Neurons Regulate Migraine‐Like Allodynia by Activating CRFR2 on Spinal Trigeminal Caudalis Glutamatergic Neurons

open access: yesAdvanced Science, EarlyView.
Paraventricular CRF neurons in the hypothalamus project to glutamatergic neurons of the spinal trigeminal caudal nucleus, enhancing neuronal activation and CRFR2 signaling. This pathway increases CRF release and excitatory drive, promoting central sensitization and migraine‐related behaviors. Targeting the PVN–SP5C circuit provides a potential strategy
Jiang Bian   +13 more
wiley   +1 more source

Kurz zum Klima: Umwelt und Demokratie

open access: yes, 2016
Der Environmental Performance Index (EPI) betrachtet die ökologische Gesamtleistung eines Landes, der Environmental Democracy Index (EDI) bildet die demokratischen Beteiligungsmöglichkeiten im Umweltbereich ab.
Leithold, Daniel, Lippelt, Jana
core  

Designing Scalable Mechano‐Virucidal Nanostructured Acrylic Surfaces for Enhanced Viral Inactivation

open access: yesAdvanced Science, EarlyView.
Can a surface be designed to physically break viruses? This study explores how nanoscale geometry—specifically the spacing of tiny pillars—can determine whether viruses remain intact or rupture. Using flexible acrylic and a scalable fabrication process, the authors develop nanopillared, transparent surfaces that show strong antiviral activity without ...
Samson W. L. Mah   +14 more
wiley   +1 more source

Determining relationship between economic growth and environmental protection [PDF]

open access: yesOditor, 2020
The subject of this paper is the analysis of the relationship between economic growth and the environment performance. The authors have investigated the EPI index while our research covered the period 2010-2018.
Ignjatijević Svetlana   +3 more
doaj  

Systematic Engineering of Proteases in Saccharopolyspora Spinosa Reveals Synergistic Enhancement of Spinosad Biosynthesis via Substrate Flux Optimization

open access: yesAdvanced Science, EarlyView.
ARTP mutagenesis yielded Saccharopolyspora spinosa mutant D184 with improved extracellular nitrogen utilization. An integrated workflow of protease genetic manipulation, multi‐omics, and rational synergy design pinpointed a pepP‐clpP‐htpX synergistic triangular combination.
Duo Jin   +9 more
wiley   +1 more source

Managing Interacting Criteria: Application to Environmental Evaluation Practices [PDF]

open access: yes, 2018
The need for organizations to evaluate their environmental practices has been recently increasing. This fact has led to the development of many approaches to appraise such practices.
Andrés Calle, Rocío de   +2 more
core   +2 more sources

SIRT1 Prevents Ferroptosis in Corneal Epithelial Cells by Enhancing HIF1α Protein Stability in Dry Eye Disease

open access: yesAdvanced Science, EarlyView.
Hyperosmotic stress drives ferroptosis in corneal epithelium via SIRT1 downregulation. This work demonstrates that SIRT1 activation stabilizes HIF1α, which transcriptionally upregulates GPX4 to inhibit lipid peroxidation and cell death. The identified SIRT1/HIF1α/GPX4 axis reveals a novel defense mechanism and potential therapy for dry eye disease ...
Lili Lian   +11 more
wiley   +1 more source

Software tools for conducting bibliometric analysis in science: An up-to-date review [PDF]

open access: yes, 2019
Bibliometrics has become an essential tool for assessing and analyzing the output of scientists, cooperation between universities, the effect of state-owned science funding on national research and development performance and educational efficiency ...
Cobo Martín, Manuel Jesús   +3 more
core   +3 more sources

A Soft Matrix Microenvironment Promotes Laterally Spreading Tumors via Oxidative Phosphorylation‐Dependent Cell Adhesion

open access: yesAdvanced Science, EarlyView.
Laterally spreading tumors (LSTs) are precancerous colorectal lesions characterized by a flat morphology. This study reveals a mechanochemical pathway through which a soft matrix microenvironment diminishes spatial constraints in intestinal adenomas. This process promotes deficiencies in tight junction proteins, mediated by the mechanoreceptor ADORA2B ...
Jiamin Zhong   +21 more
wiley   +1 more source

Exploring the interconnections between climate-green bond financing, sustainable environment and financial markets in Sub-Saharan Africa

open access: yesSustainable Futures
This study explores the relationship between climate finance, green bonds, environmental sustainability, institutional quality, and financial market development in Sub-Saharan Africa from 1995 to 2023.
Charles O. Manasseh   +6 more
doaj   +1 more source

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