Results 21 to 30 of about 9,226,648 (337)

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

FEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker, Nimit Mistry, Nicoletta Plotegher, Elizabeth R. Westbrook, Michael D. E. Sewell, John Carroll, Gyorgy Szabadkai, Angus J. Bain, Michael R. Duchen   +8 more
wiley   +1 more source

Environmental test planning, selection and standardization aids available [PDF]

, 1968
Requirements for instrumentation, equipment, and methods to be used in conducting environmental tests on components intended for use by a wide variety of technical personnel of different educational backgrounds, experience, and interests is ...
Copeland, E. H., Foley, J. T.
core   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Wind Turbines In The Landscape: Final Report & Script [PDF]

, 1994
The aim of this project was to produce a video film where the visual impact issues associated with current UK wind farms are addressed. The video is targeted to an audience of planners, planning committee members, planning consultants, environmental ...
Cook, T, Robotham, AJ
core   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Local authority provision of environmental planning guidelines for event management in Ireland

European Journal of Tourism Research, 2016
This paper discusses the environmental impacts generated by hosting events. More specifically it focuses on the case study of assessing the provision of environmental planning guidelines by Local Authorities to manage the environmental impacts of events ...
J. Hanrahan, K. Maguire
semanticscholar   +1 more source

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source

EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines

Molecular Oncology, EarlyView.
The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche, Renske Imschoot, Béatrice Lintermans, Lode Denolf, Joachim Taminau, Charlotte Fieuws, Geert Berx, Kris Gevaert, Kathleen B. M. Claes   +8 more
wiley   +1 more source

Environmental Monitoring Plan [PDF]

, 2005
The purpose of the environmental monitoring plan (EMP) is to promote the early identification of, and response to, potential adverse environmental impacts associated with DOE operations. Environmental monitoring supports the Integrated Safety Management System (ISMS) to detect, characterize, and respond to releases from DOE activities; assess impacts ...
Althouse, P. E., Bertoldo, N. A., Bowen, B. M., Brown, R. A., Campbell, C. G., Christofferson, E., Gallegos, G. M., Grayson, A. R., Jones, H. E., Larson, J. M., Laycak, D., Mathews, S., Peterson, S. R., Revelli, M. J., Rueppel, D., Williams, R. A., Wilson, K., Woods, N.   +17 more
openaire   +2 more sources

North Slope Borough water study: a background for planning [PDF]

, 1977
The Planning and Research Section of Alaska Dept. of Natural Resources initiated this pilot water study with the North Slope Borough and the University of Alaska's Arctic Environmental Information and Data Center and Institute of Water Resources ...
Dreyer, Linda Dwight, Johnson, Ronald A.
core