Results 111 to 120 of about 1,123,785 (300)

Perfluorooctanoic Acid Exposure Causes Macrophage Ammonia Retention and Induces Spontaneous Miscarriages

open access: yesAdvanced Science, EarlyView.
PFOA exposure induces pregnancy loss by promoting glutaminolysis, which further causes ammonia accumulation in macrophages. Cellular ammonia retention results in damage to mitochondria and lysosomes, which leads to cell death eventually. Impaired lysosomes also decrease the secretion of the Cathepsin B (CTSB), and attenuate macrophage infiltration and ...
Yongbo Zhao   +6 more
wiley   +1 more source

Gut Bacteria Improve Depressive Symptoms by Degrading Cortisol into Androgen

open access: yesAdvanced Science, EarlyView.
Chronic stress is an important risk factor for stress‐related disorders such as depression. Stress hormone cortisol is essential for the pathogenesis of stress‐related disorders such as depression. Some gut microbiota degraded cortisol, and improve depressive symptoms.
Xiong Wang   +12 more
wiley   +1 more source

Taurocholic Acid Is Associated With Disturbed Functional Connectivity in the Hippocampus of Patients With Depression

open access: yesAdvanced Science, EarlyView.
This study identifies elevated taurocholic acid (TCA) in Major Depressive Disorder patients. Gut microbiome‐associated TCA impairs hippocampal neurogenesis, triggers microglia activation, and elicits depression‐like behavior in mice via the S1PR2. In patients, functional neuroimaging reveals that serum TCA levels correlate with altered functional ...
Xiaoying Cai   +12 more
wiley   +1 more source

Brief Discussion on People’s Behavior Psychological Demand in Private Courtyard Space

open access: yesSHS Web of Conferences, 2015
This article mainly describes the method to apply the people’s psychological demand in the private courtyard within the scope of environmental psychology. Private courtyard is a place where the activities for house owners are carried out most frequently.
Cui Huaizu, Hu Qingqing, He Fengmiao
doaj   +1 more source

Testicular mRNA‐LNP Delivery: A Novel Therapy for Genetic Spermatogenic Disorders

open access: yesAdvanced Science, EarlyView.
In the current study, we developed a novel therapy for genetic spermatogenic disorders. It was revealed that in vivo delivery of mRNA LNP3 could restore spermatogenesis in Msh5D486Y/D486Y and Maps KO mouse models with meiotic arrest. Notably, the offspring without genomic integration was born using ICSI derived from the rescue of Msh5D486Y/D486Y mouse ...
Chenwang Zhang   +22 more
wiley   +1 more source

How perceived value, environmental awareness, and social identity shape public support for industrial heritage: the mediating role of place attachment

open access: yesFrontiers in Psychology
IntroductionPublic engagement is critical to the conservation of industrial heritage sites, yet the psychological mechanisms underlying support behaviors remain understudied.
Yinghang Fu, Weidan Dong
doaj   +1 more source

Improvements and Future Challenges in the Field of Genetically Sensitive Sample Designs [PDF]

open access: yes
Understanding the sources of individual differences beyond social and economic effects has become a research area of growing interest in psychology, sociology, and economics.
Frank M. Spinath
core  

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