Results 41 to 50 of about 12,883 (261)

Racionalidad y Justicia Ambiental: La Elusiva Injusticia de la Vida

Historia Ambiental Latinoamericana y Caribeña, 2021
Law is not justice, says the Manifesto for Life. The justice system established in modernity (the legality of a positive law) does not manage to contain the will to dominate exercised by the ontological regime of modernity over the degradation of life ...
Enrique Leff
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

The conundrum between the neoliberal rationality and the contemporary environmental crisis: Fluctuations through uncertain times

Revista Direitos Humanos e Democracia
The current investigation deals with the scope of the contemporary environmental crisis and its relationship with the neoliberal rationality. In this sense, the issue of such research comes up from the following questions: What is the future prognosis ...
Rodrigo Tonel, Daniel Rubens Cenci
doaj   +1 more source

La nuova disciplina dell’improcedibilità. Le incoerenze applicative e le irragionevoli disparità di trattamento in materia di reati ambientali e reati associativi connessi. [PDF]

Lexambiente, 2022
The article briefly describes the possible outcomes of criminal proceedings after the entry into force of Law n. 134/2021 reform on procedural inadmissibility, emphasizing the overabundance of intertemporal regulations, the contradictory choices of the ...
MONFERINI Giulio
doaj  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

USING GIS-TECHNOLOGIES IN THE LANDSCAPE AND ENVIRONMENTAL STUDIES IN ARMENIA

InterCarto. InterGIS, 2014
The main tools of GIS-technologies applied in the environmental studies of natural and anthropogenic systems in Armenia are considered in the article.
Sh. Asmaryan, V. Muradyan, A. Hovsepyan, G. Tepanosyan   +3 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source