Results 81 to 90 of about 4,677,221 (337)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Rationality Analysis of the Heihe River '97' Water Diversion Scheme under Changing Environment

Tecnología y ciencias del agua, 2019
The environmental condition has changed after the implementation of the '97' water diversion scheme, and there are still queries regarding the rationality of the water diversion scheme due to the potential difficulty of completing the releasing goal of ...
Menglong Zhao, Xiaohui Jiang, Qiang Huang, Guotao Dong   +3 more
doaj   +1 more source

Modelling of Agricultural Behavior under the CAP Regime: Policy Effectiveness and Design [PDF]

The paper discusses the design of optimal regulatory policies under an alternative analytical framework of unbounded and bounded rationality, by considering the mechanism that provides the type of the optimal CAP instruments that ensure the collective ...
Anastasios Xepapadeas, Constadina Passa
core  

Law for the Common Man: An Individual-Level Theory of Values, Expanded Rationality, and the Law [PDF]

, 2011
This article makes an admittedly bold attempt at outlining an analytical framework for addressing this question. Instead of looking at the legal implications of bounded rationality -- an exercise highly worthy in its own right -- this article advances a ...
Licht, Amir N.
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Discussions on the value of nature from the perspective of political ecology: Castrian logic as Latin American socio-metabolic potential and negentropic productivity as territorialization for live

Terr@ Plural
The proposed text synthesizes the urgency, challenges, and alternatives for the ecological turn in terms of Political Ecology. Thus, drawing support from the recent works of Enrique Leff (2021), we investigate the ...
João Francisco de Oliveira Neto, Ivair Gomes, Arlon Cândido Ferreira   +2 more
doaj   +1 more source

Are emotions reliable guides for policy making? An evolutionary perspective [PDF]

, 2014
Technology has become all-important in modern society. For each application, it is crucial for society to have a good understanding of the risks and benefits involved. However, experts tend to assess the risks very differently than the public. One of the
Blancke, Stefaan
core   +1 more source

Pengaruh Perilaku Konsumsi di Lingkungan Keluarga terhadap Rasionalitas Ekonomi Siswa Smk Negeri 3 Pontianak [PDF]

, 2016
This study raised concerns about Consumption Behaviors in Environmental Families Against Economic Rationality SMK Negeri 3 Pontianak. This study aims to determine how much influence the behavior konsusmi in the family environment on economic rationality.
Sartika, D. (Dewi), Syahrudin, H. (Husni), Witarsa, W. (Witarsa)   +2 more
core   +2 more sources

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Environmental Policy when People's Preferences are Inconsistent, Non-Welfaristic, or simply Not Developed [PDF]

This paper discusses how a benevolent policy maker should act based on some, possibly non-welfaristic,ethical principle in cases where people's preferences are not perfectly informed,consistent and fully developed with regard to all goods, including all ...
Johansson-Stenman, Olof
core