Results 31 to 40 of about 1,490,052 (312)

Environmental Risks to Kidney Health [PDF]

Clinical Journal of the American Society of Nephrology, 2020
Environmental pollution is well recognized as a threat to public health. The United States Environmental Protection Agency, the federal agency charged with protecting human health and the environment, was established 50 years ago and now has a budget of $8.8 billion and 14,172 employees ...
openaire   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Change over time of the mutagenicity in the lungs of gpt delta transgenic mice by extract of airborne particles collected from ambient air in the Tokyo metropolitan area

Genes and Environment, 2018
Background Previously we found that DNA adducts were accumulated in the lungs of the rats exposed to ambient air in the Tokyo metropolitan area. To examine chronological change in in vivo mutagenicity of airborne particles, extracts produced from samples
Yasunobu Aoki, Daisuke Nakajima, Michiyo Matsumoto, Mayuko Yagishita, Michi Matsumoto, Rie Yanagisawa, Sumio Goto, Kenichi Masumura, Takehiko Nohmi   +8 more
doaj   +1 more source

Multi-objective optimal design for flood risk management with resilience objectives

, 2018
In flood risk management, the divergent concept of resilience of a flood defense system cannot be fully defined quantitatively by one indicator and multiple indicators need to be considered simultaneously.
Su, Hsin-Ting, Hsin-Ting Su, Cheung, Sai Hung, Edmond Yat-Man Lo, Su, Hsin Ting, Lo, Edmond Yat-Man, Sai Hung Cheung, Lo, Edmond Yat Man   +7 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Chemical Compositions and Source Analysis of PM2.5 during Autumn and Winter in a Heavily Polluted City in China

Atmosphere, 2020
As one of the biggest cities in North China, Jinan has been suffering heavy air pollution in recent decades. To better characterize the ambient particulate matter in Jinan during heavy pollution periods, we collected daily PM2.5 (particulate matter with ...
Shasha Tian, Yingying Liu, Jing Wang, Jian Wang, Lujian Hou, Bo Lv, Xinhua Wang, Xueyan Zhao, Wen Yang, Chunmei Geng, Bin Han, Zhipeng Bai   +11 more
doaj   +1 more source

Contributions to resource and environmental risk management [PDF]

, 2009
The rest of this DSc thesis is made up of published articles, as listed in the PDF attached to this record.This thesis charts a research journey through the disciplines of waste chemistry, environmental risk assessment, policy analysis and corporate ...
Pollard, Simon J T, Pollard, Simon J. T.
core  

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source