Results 111 to 120 of about 892,996 (295)

Epitranscriptomic alterations induced by environmental toxins: implications for RNA modifications and disease

Genes and Environment
Epitranscriptomics, the study of chemical modifications on RNA molecules, has emerged as a vital regulatory layer in gene expression. Among the numerous RNA modifications, N6-methyladenosine (m6A), 5-methylcytosine (m5C), and pseudouridine (Ψ) are ...
Esther Ugo Alum, Regina Idu Ejemot-Nwadiaro, Mariam Basajja, Daniel Ejim Uti, Okechukwu Paul-Chima Ugwu, Patrick Maduabuchi Aja   +5 more
doaj   +1 more source

Chloroplast- or Mitochondria-Targeted DEAD-Box RNA Helicases Play Essential Roles in Organellar RNA Metabolism and Abiotic Stress Responses

Frontiers in Plant Science, 2017
The yields and productivity of crops are greatly diminished by various abiotic stresses, including drought, cold, heat, and high salinity. Chloroplasts and mitochondria are cellular organelles that can sense diverse environmental stimuli and alter gene ...
Ghazala Nawaz, Hunseung Kang
doaj   +1 more source

Evidence linking exposure of fish primary macrophages to antibiotics activates the NF-kB pathway. [PDF]

, 2020
Low doses of antibiotics are ubiquitous in the marine environment and may exert negative effects on non-target aquatic organisms. Using primary macrophages of common carp, we investigated the mechanisms of action following exposure to several common ...
Chen, Qiqing, Fang, Meijuan, Greer, Justin, Hu, Jiaqi, Magnuson, Jason T, Qiu, Wenhui, Schlenk, Daniel, Yang, Ming, Zheng, Chunmiao   +8 more
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

RNA sequencing of early round goby embryos reveals that maternal experiences can shape the maternal RNA contribution in a wild vertebrate

BMC Evolutionary Biology, 2018
Background It has been proposed that non-genetic inheritance could promote species fitness. Non-genetic inheritance could allow offspring to benefit from the experience of their parents, and could advocate pre-adaptation to prevailing and potentially ...
Irene Adrian-Kalchhauser, Jean-Claude Walser, Michaela Schwaiger, Patricia Burkhardt-Holm   +3 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

The genomic impact of population connectivity and decline in Africa’s elephants

Nature Communications
African elephants are keystone species facing severe declines due to the ivory trade and habitat loss. To investigate the genomic consequences, we analyze 232 high-coverage genomes from 17 African countries in the first continent-wide genomic analysis ...
Patrícia Pečnerová, Yasuko Ishida, Genís Garcia-Erill, Laura D. Bertola, Cindy G. Santander, Xiaodong Liu, Anna Brüniche-Olsen, Anubhab Khan, Lauren M. Hennelly, Renzo F. Balboa, Long Lin, Malthe S. Rasmussen, Xi Wang, Mikkel Schubert, Amal Al-Chaer, Sylwia Urbaniak, Kan Nobuta, Sasha Treadup, Karine A. Viaud-Martinez, Alida de Flamingh, Ripan S. Malhi, Savanah Bird, Nelson Ting, Mrinalini Watsa, Martin N. Tchamba, Stéphanie Bourgeois, Chris Thouless, Iain Douglas-Hamilton, George Wittemyer, Peter J. Van Coeverden de Groot, Vincent B. Muwanika, Charles Masembe, Nicholas J. Georgiadis, Christina Hvilsom, Rasmus Heller, Hans Redlef Siegismund, Alfred L. Roca   +36 more
doaj   +1 more source

Application of integrated nested Laplace approximation to identify hot spots of methylation heterogeneity in healthy individuals from the MAMELI cohort

Frontiers in Genetics
DNA methylation is an epigenetic regulator of gene expression and cell identity, which can be shaped by both physiological and pathological factors, including environmental exposure.
Tiago Nardi, Eva Dariol, Rachele Matsagani, Donya Zojaji, Stefano Gustincich, Luca Pandolfini, Elia Biganzoli, Valentina Bollati   +7 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source