Results 91 to 100 of about 525,778 (258)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Building Field-Ready Environmental RNA Panels

Environmental RNA (eRNA) has been increasingly used to move beyond “who is there” toward “who is active” and “what is happening” in ecosystems. Yet, most workflows have been optimized for laboratory sequencing, and decision-grade field use has remained sporadic.
Mehran Khorshid, Zahra Alizadeh Khatibani, Ehsan Pashay Ahi   +2 more
openaire   +1 more source

Self-Assembling RNA Nanostructures are Highly Sensitive to Environmental Conditions

Journal of Molecular Biology
Recent developments in RNA nanotechnology have led to an increase in the design of specific, higher-order RNA structures, which will ultimately be used in drug delivery and immunomodulation applications. As researchers create RNA nanostructures with the intention of making them a standard tool in molecular biologists' toolkits, further investigation is
Jordan Aposhian, Surya Pratap S. Deopa, Scott Horowitz, Joseph D. Yesselman   +3 more
openaire   +2 more sources

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Diversity and distinctive characteristics of the global RNA virome in urban and peri-urban environments

Nature Communications
RNA viruses represent an integral component of human-associated environments and human health. However, the ecology of environmental RNA viruses remains largely unexplored.
Zihao Gao, Jun Wu, Alexander G. Lucaci, Jian Ouyang, Lan Wang, Krista A. Ryon, Eran Elhaik, Alexander J. Probst, Xavier Rodó, Thirumalaisamy P. Velavan, Anastasia Chasapi, Christos A. Ouzounis, Manuela Oliveira, Emmanuel Dias-Neto, Olayinka Osuolale, Michael Poulsen, Dmitry Meleshko, Malay Bhattacharyya, Juan A. Ugalde, Alba Tull, Kathleen H. Rubins, Maria A. Sierra, Braden T. Tierney, Bharath Prithiviraj, Nitesh Kumar Sharma, Viorel Munteanu, Serghei Mangul, Kubra Can Kurt, Masayuki Ushio, Natalia Mazur-Panasiuk, Katarzyna Kopera, Kamila Marszałek, Michał Kowalski, Rodolfo Brizola Toscan, Wojciech Branicki, Krzysztof Pyrć, Paweł P. Łabaj, Balakrishnan Subramanian, Alina Frolova, Joshua G. Burkhart, Youping Deng, Klas I. Udekwu, Lynn M. Schriml, Nur Hazlin Hazrin-Chong, Haruo Suzuki, Patrick K. H. Lee, Antonio Pedro Camargo, Nikos C. Kyrpides, Di Liu, Lin-Fa Wang, Christopher E. Mason, Tieliu Shi, The International MetaSUB Consortium   +52 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source