Results 91 to 100 of about 892,996 (295)

Cellular decision-making bias: the missing ingredient in cell functional diversity

, 2013
Cell functional diversity is a significant determinant on how biological processes unfold. Most accounts of diversity involve a search for sequence or expression differences. Perhaps there are more subtle mechanisms at work.
Alicea, Bradly
core   +2 more sources

The use of mycoviruses in the control of forest diseases [PDF]

, 2016
Producción CientíficaFifteen families of mycoviruses have been described and 80% of these catalogued. However, their evolutionary relationship with fungi is not clear.
Díez Casero, Julio Javier, Fernández Fernández, María Mercedes, Muñoz Adalia, Emigdio Jordán   +2 more
core   +1 more source

The Promise of Environmental RNA Research Beyond mRNA

Molecular Ecology
ABSTRACTEnvironmental RNA (eRNA) studies have primarily focused on species detection and community composition through metabarcoding or metatranscriptomics, and on gene expression through messenger RNA (mRNA) abundance analysis. While valuable, this focus overlooks the broader functional roles of other RNA types in cellular metabolism.
Ehsan Pashay Ahi, Tamara Schenekar
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Integrated Regulatory and Metabolic Networks of the Marine Diatom Phaeodactylum tricornutum Predict the Response to Rising CO2 Levels. [PDF]

, 2017
Diatoms are eukaryotic microalgae that are responsible for up to 40% of the ocean's primary productivity. How diatoms respond to environmental perturbations such as elevated carbon concentrations in the atmosphere is currently poorly understood.
Andrew E. Allen, Bernhard O. Palsson, Christopher L. Dupont, Jennifer Levering, Karsten Zengler, Xiaoxia Lin   +5 more
core   +3 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Environmental RNA as a transformative tool for aquatic ecosystem health assessment: progress and challenges

Ecological Indicators
The assessment of aquatic ecosystem health is undergoing a paradigm shift from traditional physicochemical monitoring to molecular biological monitoring.
Ningxi Zou, Shuhang Wang, Wenhui Qiu, Weijing Kong, Guangwei Wang, Shuping Wang   +5 more
doaj   +1 more source

Endomicroscopic and transcriptomic analysis of impaired barrier function and malabsorption in environmental enteropathy [PDF]

, 2016
Introduction: Environmental enteropathy (EE) is associated with growth failure, micronutrient malabsorption and impaired responses to oral vaccines.
A Prendergast, A Veitch, AC Illing, AJ Prendergast, Alastair Watson, AM Marchiando, AM Marchiando, AM Marchiando, AR Tenorio, B Sandström, Beatrice Amadi, D Gunzel, DI Campbell, E Salazar-Lindo, Ellen Besa, EM Vestergaard, G Marchetti, GC Cook, GT Keusch, J Brenchley, J Vesterbacka, J Zulu, James Lees, JH Humphrey, JM Williams, John Louis-Auguste, JR Turner, Kanekwa Zyambo, L Aamann, L Bremholm, LG Lim, LS Valberg, M Kosek, MH Wojcik, MJ Manary, MM Levine, MS Wapenaar, N Kimer, P Bellot, P Janssen, P Kelly, P Kelly, P Kelly, Paul Kelly, PB Jeppesen, Q Xiao, R Kiesslich, R Kiesslich, RL Guerrant, Rose Soko, Rosemary Banda, S Baldassano, S Tarazona, T Mizuno, Themba Banda, U Trautvetter, V Giorgio, VF Zevallos, W Dhaliwal, WA Petri, William A. Petri, Y Guan   +61 more
core   +5 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Stable isotope probing: Technical considerations when resolving ¹⁵N-labeled RNA in gradients [PDF]

, 2010
RNA based stable isotope probing (SIP) facilitates the detection and identification of active members of microbial populations that are involved in the assimilation of an isotopically labeled compound.
Addison, Sarah Louise, Lloyd-Jones, Gareth, McDonald, Ian R.   +2 more
core   +2 more sources