Results 71 to 80 of about 525,778 (258)

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Epitranscriptomic alterations induced by environmental toxins: implications for RNA modifications and disease

Genes and Environment
Epitranscriptomics, the study of chemical modifications on RNA molecules, has emerged as a vital regulatory layer in gene expression. Among the numerous RNA modifications, N6-methyladenosine (m6A), 5-methylcytosine (m5C), and pseudouridine (Ψ) are ...
Esther Ugo Alum, Regina Idu Ejemot-Nwadiaro, Mariam Basajja, Daniel Ejim Uti, Okechukwu Paul-Chima Ugwu, Patrick Maduabuchi Aja   +5 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

The genomic impact of population connectivity and decline in Africa’s elephants

Nature Communications
African elephants are keystone species facing severe declines due to the ivory trade and habitat loss. To investigate the genomic consequences, we analyze 232 high-coverage genomes from 17 African countries in the first continent-wide genomic analysis ...
Patrícia Pečnerová, Yasuko Ishida, Genís Garcia-Erill, Laura D. Bertola, Cindy G. Santander, Xiaodong Liu, Anna Brüniche-Olsen, Anubhab Khan, Lauren M. Hennelly, Renzo F. Balboa, Long Lin, Malthe S. Rasmussen, Xi Wang, Mikkel Schubert, Amal Al-Chaer, Sylwia Urbaniak, Kan Nobuta, Sasha Treadup, Karine A. Viaud-Martinez, Alida de Flamingh, Ripan S. Malhi, Savanah Bird, Nelson Ting, Mrinalini Watsa, Martin N. Tchamba, Stéphanie Bourgeois, Chris Thouless, Iain Douglas-Hamilton, George Wittemyer, Peter J. Van Coeverden de Groot, Vincent B. Muwanika, Charles Masembe, Nicholas J. Georgiadis, Christina Hvilsom, Rasmus Heller, Hans Redlef Siegismund, Alfred L. Roca   +36 more
doaj   +1 more source

Chloroplast- or Mitochondria-Targeted DEAD-Box RNA Helicases Play Essential Roles in Organellar RNA Metabolism and Abiotic Stress Responses

Frontiers in Plant Science, 2017
The yields and productivity of crops are greatly diminished by various abiotic stresses, including drought, cold, heat, and high salinity. Chloroplasts and mitochondria are cellular organelles that can sense diverse environmental stimuli and alter gene ...
Ghazala Nawaz, Hunseung Kang
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Application of integrated nested Laplace approximation to identify hot spots of methylation heterogeneity in healthy individuals from the MAMELI cohort

Frontiers in Genetics
DNA methylation is an epigenetic regulator of gene expression and cell identity, which can be shaped by both physiological and pathological factors, including environmental exposure.
Tiago Nardi, Eva Dariol, Rachele Matsagani, Donya Zojaji, Stefano Gustincich, Luca Pandolfini, Elia Biganzoli, Valentina Bollati   +7 more
doaj   +1 more source

RNA sequencing of early round goby embryos reveals that maternal experiences can shape the maternal RNA contribution in a wild vertebrate

BMC Evolutionary Biology, 2018
Background It has been proposed that non-genetic inheritance could promote species fitness. Non-genetic inheritance could allow offspring to benefit from the experience of their parents, and could advocate pre-adaptation to prevailing and potentially ...
Irene Adrian-Kalchhauser, Jean-Claude Walser, Michaela Schwaiger, Patricia Burkhardt-Holm   +3 more
doaj   +1 more source

Comparative environmental RNA and DNA metabarcoding analysis of river algae and arthropods for ecological surveys and water quality assessment. [PDF]

Sci Rep, 2022
Miyata K, Inoue Y, Amano Y, Nishioka T, Nagaike T, Kawaguchi T, Morita O, Yamane M, Honda H.   +8 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source