Results 81 to 90 of about 892,996 (295)

Environmental perturbations lead to extensive directional shifts in RNA processing

PLOS Genetics, 2017
AbstractEnvironmental perturbations have large effects on both organismal and cellular traits, including gene expression, but the extent to which the environment affects RNA processing remains largely uncharacterized. Recent studies have identified a large number of genetic variants associated with variation in RNA processing that also have an ...
Allison L. Richards, Donovan Watza, Anthony Findley, Adnan Alazizi, Xiaoquan Wen, Athma A. Pai, Roger Pique-Regi, Francesca Luca   +7 more
openaire   +5 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

The impact of molecular biology on assessment of water quality: advantages and limitations of current techniques [PDF]

, 1997
The advent of molecular biology has had a dramatic impact on all aspects of biology, not least applied microbial ecology. Microbiological testing of water has traditionally depended largely on culture techniques.
Saunders, J.R., Saunders, V.A.
core  

Seasonal changes in the biochemical fate of carbon fixed by benthic diatoms in intertidal sediments [PDF]

, 2018
Benthic diatoms are important primary producers in intertidal marine sediments and form the basis of the food web in these ecosystems. In order to investigate the carbon flow within diatom mats, we performed in situ 13C pulse-chase labeling experiments ...
Admiraal, Allen, Armbrust, Barnett, Bellinger, Bender, Berman, Blazewicz, Boschker, Boschker, Bouillon, Brouwer, Brown, Buma, Cahoon, Chen, Chessel, Como, Consalvey, Cowie, Degré, Dijkman, Dolédec, Dray, Eilers, Escoufier, Evrard, Fields, Goto, Goto, Guschina, Hanlon, Heinzelmann, Heo, Herman, Herman, Hillebrand, Hockin, Hu, Jiang, Jones, Jonge, Kromkamp, Kroth, Kuczynska, Lee, Levitan, Litchman, MacIntyre, McCullagh, Middelburg, Mitbavkar, Miyajima, Miyatake, Moerdijk-Poortvliet, Moerdijk-Poortvliet, Oakes, Oevelen, Peletier, Pierre, Pinckney, Pniewski, Prihoda, R Development Core Team, Rawat, Sabbe, Sakthivel, Serôdio, Serôdio, Smith, Stal, Stewart, Taylor, Telfer, Therkildsen, Thornton, Underwood, Underwood, Underwood, Underwood, Veuger, Veuger   +81 more
core   +3 more sources

Potential roles of noncoding RNAs in environmental epigenetic transgenerational inheritance [PDF]

Molecular and Cellular Endocrinology, 2014
"Epigenetic transgenerational inheritance" (ETI) has been defined as germline (sperm or egg) transmission of epigenetic information between generations in the absence of direct exposures or genetic manipulations. Among reported cases of ETI in mammals, the majority are induced by environmental factors, including environmental toxicants [e.g ...
openaire   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

A higher order PUF complex is central to regulation of C. elegans germline stem cells

Nature Communications
PUF RNA-binding proteins are broadly conserved stem cell regulators. Nematode PUF proteins maintain germline stem cells (GSCs) and, with key partner proteins, repress differentiation mRNAs, including gld-1.
Chen Qiu, Sarah L. Crittenden, Brian H. Carrick, Lucas B. Dillard, Stephany J. Costa Dos Santos, Venkata P. Dandey, Robert C. Dutcher, Elizabeth G. Viverette, Robert N. Wine, Jennifer Woodworth, Zachary T. Campbell, Marvin Wickens, Mario J. Borgnia, Judith Kimble, Traci M. Tanaka Hall   +14 more
doaj   +1 more source

The direct and indirect drivers shaping RNA viral communities in grassland soils

mSystems
Recent studies have revealed diverse RNA viral communities in soils. Yet, how environmental factors influence soil RNA viruses remains largely unknown. Here, we recovered RNA viral communities from bulk metatranscriptomes sequenced from grassland soils ...
Ruonan Wu, Amy E. Zimmerman, Kirsten S. Hofmockel   +2 more
doaj   +1 more source

Comparing the Influence of Assembly Processes Governing Bacterial Community Succession Based on DNA and RNA Data

Microorganisms, 2020
Quantifying which assembly processes structure microbiomes can assist prediction, manipulation, and engineering of community outcomes. However, the relative importance of these processes might depend on whether DNA or RNA are used, as they differ in ...
Xiu Jia, Francisco Dini-Andreote, Joana Falcão Salles   +2 more
doaj   +1 more source