Results 91 to 100 of about 24,035,647 (351)
Environmental Toxicology and Chemistry, 2018 In vitro assays and high‐throughput screening (HTS) tools are increasingly being employed as replacements for animal testing, but most concentration–response curves are still evaluated with models developed for animal testing.
B. Escher, P. Neale, D. Villeneuve
semanticscholar +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
A theory of the impediments to environmental tax reform [PDF]
, 2001 Environmental Tax Reform (ETR) is widely accepted to be a policy with desirable environmental, and other economic effects. The question arises then as to why its implementation has been so patchy. There is a broad literature on the economic impact of ETR,
Clinch, J. Peter, Dunne, Louise
core +1 more source
Methods for the extraction, storage, amplification and sequencing of DNA from environmental samples
, 2018 Advances in the sequencing of DNA extracted from media such as soil and water offer huge opportunities for biodiversity monitoring and assessment, particularly where the collection or identification of whole organisms is impractical.
G. Lear +17 more
semanticscholar +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Journal of Pure and Applied Microbiology, 2020 Nosocomial infections mainly are due to inefficient cleaning in association with the uncontrollable prescription of antimicrobials resulting in the emergence of multi-drug resistant pathogens in the hospital environment.
Rehab Mahmoud Abd El-Baky +4 more
doaj +1 more source
Scientific Data, 2017 Mitochondrial-encoded genes are increasingly targeted in studies using high-throughput sequencing approaches for characterizing metazoan communities from environmental samples (e.g., plankton, meiofauna, filtered water). Yet, unlike nuclear ribosomal RNA
R. Machida +3 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Current and Emerging Analytical Techniques for the Determination of PFAS in Environmental Samples
Trends in Environmental Analytical Chemistry, 2023 Abd ur Rehman, M. Crimi, S. Andreescu
semanticscholar +1 more source
, 2023 Although mining contributes to about 1.4% of Fiji’s gross domestic product (GDP), the excavated rocks from mining may have detrimental effects on the environment.
Walubita Mufalo +4 more
core +1 more source