Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
wiley +1 more source
Relevant environmental science [PDF]
Environmental Toxicology and Chemistry, 2003 Raymond C. Loehr, Peter M. Chapman
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Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer
Molecular Oncology, EarlyView.Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte +10 more
wiley +1 more source
Embracing the Intersections of Environmental Science, Engineering, and Geosciences to Solve Grand Challenges of the 21st Century. [PDF]
Environ Sci Technol, 2023 Deng H, Giammar D, Li W, Vengosh A.
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Molecular Oncology, EarlyView.The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song +11 more
wiley +1 more source
Tropospheric Ozone: A Critical Review of the Literature on Emissions, Exposure, and Health Effects
AtmosphereTropospheric ozone is a significant air pollutant with severe adverse effects on human health. The complex dynamics of ozone formation, distribution, and health impacts underscore the need for a comprehensive understanding of this pollutant. Despite well-
Gabriele Donzelli +1 more
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The impact of plastic during the COVID-19 pandemic: The point of view of the environmental science literature. [PDF]
Mater Today Proc, 2023 de Sousa FDB.
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GRIFFITH, E. J., A. BEETON, J. M. SPENCER, AND D. T. MITCHELL [Eds.] 1973. Environmental phosphorus handbook. Wiley‐Inter‐science. New York, London, Sydney, Toronto, xvi + 718 p. $34.95. [PDF]
, 1974 W. T. Edmondson
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Molecular Oncology, EarlyView.Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop +10 more
wiley +1 more source
Where to restore: Connectivity forest for spatial prioritization in forest landscape restoration
iScienceSummary: Forest loss, fragmentation, and transformation negatively impact forest biodiversity and ecosystem functionality worldwide. Improving landscape intactness and connectivity through restoration is critical.
Xiaoming Wang +8 more
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