Results 141 to 150 of about 12,033,968 (396)

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

open access: yesMolecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho   +11 more
wiley   +1 more source

Enabling FAIR data in Earth and environmental science with community-centric (meta)data reporting formats. [PDF]

open access: yesSci Data, 2022
Crystal-Ornelas R   +26 more
europepmc   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

open access: yesMolecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp   +13 more
wiley   +1 more source

Online Community and Citizen Science supports environmental science learning by young people. [PDF]

open access: yesComput Educ, 2022
Herodotou C   +7 more
europepmc   +1 more source

EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines

open access: yesMolecular Oncology, EarlyView.
The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche   +8 more
wiley   +1 more source

Toward Non-Taxonomic Structuring of Scientific Notions: The Case of the Language of Chemistry and the Environment

open access: yesLanguages
This paper addresses the crucial question of the structuring of scientific Notions for the purpose of their proper teaching/acquisition. It aims to demonstrate that non-taxonomic structures, derived from the systematic lexicographic definition of ...
Tomara Gotkova   +3 more
doaj   +1 more source

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