Results 91 to 100 of about 1,541,248 (268)

Replication across space and time must be weak in the social and environmental sciences. [PDF]

Proc Natl Acad Sci U S A, 2021
Goodchild MF, Li W.
europepmc   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Protocol for constructing an accessible exposure chamber for in vitro and in vivo modeling of airway environmental exposures

STAR Protocols
Summary: Exposure systems to study the effects of environmental exposures can be costly to purchase and difficult to use. Here, we present an accessible and cost-effective approach to building an exposure chamber in the lab.
Abdo Durra, Caroline Cherry, Coline Luo, Emily Huo, Isabella Passamano, Kristen Castillo, Andrew J. Lund, Woosuk Choi, Chandani Sen, Rachana Chandran, Tammy M. Rickabaugh, Brigitte N. Gomperts   +11 more
doaj   +1 more source

Challenging the "old boys club" in academia: Gender and geographic representation in editorial boards of journals publishing in environmental sciences and public health. [PDF]

PLOS Glob Public Health, 2022
Dada S, van Daalen KR, Barrios-Ruiz A, Wu KT, Desjardins A, Bryce-Alberti M, Castro-Varela A, Khorsand P, Santamarta Zamorano A, Jung L, Malolos G, Li J, Li J, Vervoort D, Hamilton NC, Patil P, El Omrani O, Wangari MC, Sibanda T, Buggy C, Mogo ERI.   +20 more
europepmc   +1 more source

The role of data science in environmental digital twins: In praise of the arrows [PDF]

, 2023
Gordon S. Blair, Peter A. Henrys
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Protocol to sequence markers from pollen grains carried by long-range migratory butterflies using metabarcoding

STAR Protocols
Summary: Molecular identification of pollen carried by insects informs about their history of visited plants. For migratory butterflies, it can be used to trace long-range movements enduring days of flight over thousands of kilometers. Here, we present a
Johanna Luise Gorki, Tomasz Suchan, Gerard Talavera   +2 more
doaj   +1 more source

The Bibliometric Literature on Scopus and WoS: The Medicine and Environmental Sciences Categories as Case of Study. [PDF]

Int J Environ Res Public Health, 2021
Cascajares M, Alcayde A, Salmerón-Manzano E, Manzano-Agugliaro F.   +3 more
europepmc   +1 more source

Community science participants gain environmental awareness and contribute high quality data but improvements are needed: insights from Bumble Bee Watch

, 2020
Victoria J. MacPhail, Shelby D. Gibson, Sheila R. Colla   +2 more
openalex   +1 more source