Results 91 to 100 of about 4,106,632 (313)

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

How the Marsden Fund has failed to achieve its full potential in the ESA panel: evidence of limitations in scope, biased outcomes, and futile applications [PDF]

, 2014
We have analysed the scope of proposals funded by the ‘Earth Sciences and Astronomy’ (ESA) panel of the Marsden Fund for the period 2004 to 2013.
Bryan, Karin R., Lowe, David J.
core   +1 more source

Welcome to Journal of Ethnobiology and Ethnomedicine [PDF]

, 2005
Ethnobiology is a multidisciplinary field of study that draws on approaches and methods from both the social and biological sciences. Ethnobiology aims at investigating culturally based biological and environmental knowledge, cultural perception and ...
Leimar Price, L., Pieroni, Andrea, Vandebroek, I.   +2 more
core   +3 more sources

The zinc finger domains of PARP‐1 are selectively and potently inhibited by the Au(I)‐based drugs sodium aurothiomalate and aurothioglucose

FEBS Letters, EarlyView.
PARP‐1 is a key enzyme in the DNA damage response, and its inhibition induces cancer cell death via synthetic lethality. Au(I)‐based drugs, such as aurothioglucose and sodium aurothiomalate, block PARP‐1's DNA‐dependent activity by targeting its zinc finger domains.
Uliana Bashtanova, Melinda Jane Duer
wiley   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Elucidating Best Geospatial Estimation Method Applied to Environmental Sciences. [PDF]

Bull Environ Contam Toxicol, 2023
de Lourdes Berrios Cintrón M, Broomandi P, Cárdenas-Escudero J, Cáceres JO, Galán-Madruga D.   +4 more
europepmc   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Tabular strategies for metadata in ecology, evolution, and the environmental sciences. [PDF]

Ecol Evol, 2022
Lortie CJ, Vargas Poulsen C, Brun J, Kui L.   +3 more
europepmc   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Co-Constructing “Third Spaces” for Engagement with and for Minoritized Community Groups and Environmental Scientists

Earth Science, Systems and Society
The demographics of environmental and Earth scientists are not representative of the UK’s multicultural society. We sought to widen diversity and engage equitably through two related engaged research projects, “Walking the Walk” and “Landscape Stories ...
Richard Holliman, Geeta Ludhra, Clare Janet Warren, Anjana Khatwa, Yoseph Araya, Kelly Smith, Janice Ansine, Marcus Peter Sebastian Badger   +7 more
doaj   +1 more source