Results 111 to 120 of about 1,933,044 (298)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Consultation on Information in Sanitary Engineering and Environmental Sciences : final report

, 1977
Meeting: Consultation Group on Information in Sanitary Engineering and Environmental Sciences, 14-16 Nov.
Pan American Center for Sanitary Engineering and Environmental Sciences, IDRC   +1 more
core  

Democratizing education: Open schooling engaged the less privileged in environmental sciences. [PDF]

PLoS One, 2022
Wam HK, Goździk A, Aspholm PE, Juńczyk T.   +3 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Dept. of Crop Soil and Environmental Sciences, Head Lines #24

, 2015
Reflections and updates from the department head of Crop Soil and Environmental ...
Thompson, Thomas L.
core  

Swimming and the human microbiome at the intersection of sports, clinical, and environmental sciences: A scoping review of the literature. [PDF]

Front Microbiol, 2022
Puce L, Hampton-Marcell J, Trabelsi K, Ammar A, Chtourou H, Boulares A, Marinelli L, Mori L, Cotellessa F, Currà A, Trompetto C, Bragazzi NL.   +11 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dept. of Crop Soil and Environmental Sciences, Head Lines #25

, 2016
Reflections and updates from the department head of Crop Soil and Environmental ...
Thompson, Thomas L.
core  

Increasing collaboration between China and India in the environmental sciences to foster global sustainability. [PDF]

Ambio, 2022
Goodale E, Mammides C, Mtemi W, Chen YF, Barthakur R, Goodale UM, Jiang A, Liu J, Malhotra S, Meegaskumbura M, Pandit MK, Qiu G, Xu J, Cao KF, Bawa KS.   +14 more
europepmc   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source