Results 131 to 140 of about 4,260,167 (292)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Explaining international co-authorship in global environmental change research [PDF]

This paper maps the domain of earth and environmental sciences (EES) and investigates the relationship between cognitive problem structures and internationalisation patterns, drawing on the concepts of systemic versus cumulative global environmental ...
Jappe-Heinze, Arlette
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Protocol for assessing neighborhood physical disorder using the YOLOv8 deep learning model

STAR Protocols
Summary: Neighborhood physical disorder (PD), characterized by disruptions and irregularities in spatial elements, is associated with negative economic, social, and public health outcomes. Here, we present a protocol to quantitatively assess PD utilizing
Yan Li, Yue Ma, Ying Long
doaj   +1 more source

The Bibliometric Literature on Scopus and WoS: The Medicine and Environmental Sciences Categories as Case of Study. [PDF]

Int J Environ Res Public Health, 2021
Cascajares M, Alcayde A, Salmerón-Manzano E, Manzano-Agugliaro F.   +3 more
europepmc   +1 more source

Science or fiction? What the anthropocene means for EPT [PDF]

, 2018
How should environmental political theorists deal with environmental science? The question has acquired a new urgency with the rise of the Anthropocene, a geological-cum-ecological concept received with skepticism by many political theorists.
Arias-Maldonado, Manuel Jesus
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Protocol for geographical mapping of pesticide contamination

STAR Protocols
Summary: Pesticide residues in the environment threaten agricultural and human health. Here, we present a framework for mapping and comparing the contamination levels of pesticides across specific environmental compartments in various regions.
Yabi Huang, Zijian Li
doaj   +1 more source

Does Environmental Economics lead to patentable research?

, 2019
In this feasibility study, the impact of academic research from social sciences and humanities on technological innovation is explored through a study of citations patterns of journal articles in patents.
Hu, Xiaojun, Rousseau, Ronald, Rousseau, Sandra   +2 more
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source