Results 81 to 90 of about 12,186,927 (332)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

International recognition for UCT Open Educational Resources: Dr Gina Ziervogel wins OpenCourseWare Excellence Award [PDF]

open access: yes, 2012
We here at OpenUCT and the Centre for Educational Technology (CET) are proud to announce that going online with materials from one of her courses has won Dr Gina Ziervogel, a lecturer in the Environmental and Geographical Sciences Department here at UCT,
Goodier, Sarah
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Environmental Biotechnology Research Group: Research Report. [PDF]

open access: yes, 2009
Environmental biotechnology exploits living organisms (plant, bacteria, fungi, etc) in various applications of waste treatment and remediation of pollutants.
Faculty of Biotechnology & Biomolecular Sciences, Environmental Biotechnology Research Group
core   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Arkansas Small-Grain Cultivar Performance Tests 2004-2005 [PDF]

open access: yes, 2005
Small-grain cultivar performance tests are conducted each year in Arkansas by the Arkansas Agricultural Experiment Station, Department of Crop, Soil and Environmental Sciences.
Bacon, R. K.   +2 more
core   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

A Review of the Isotope System of Cadmium and Its Applications in Geosciences and Environmental Sciences

open access: yesYankuang ceshi, 2013
Cadmium is a typical chalcophile element which occurs in various sulfide deposits. In the environmental system, cadmium as the nutritional requirement is utilized for the growth of microorganisms, and its cycle is greatly affected by the biological ...
WANG Dan-ni   +4 more
doaj  

A new scenario framework for climate change research: background, process, and future directions [PDF]

open access: yes, 2013
The scientific community is developing new global, regional, and sectoral scenarios to facilitate interdisciplinary research and assessment to explore the range of possible future climates and related physical changes that could pose risks to human and ...
Arnell, NIgel   +14 more
core   +3 more sources

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