Results 31 to 40 of about 234,590 (251)

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Residents’ perceptions towards illegal household solid waste disposal: A case of Chegutu, Zimbabwe

Smart Construction and Sustainable Cities
Solid waste management has been a daunting problem in Zimbabwe over the past few years. The research sought to examine residents’ knowledge, attitudes and perceptions towards illegal household solid waste disposal in ward 8, Chegutu.
Tatenda Musasa, Amato Chireshe, Steven Jerie, Thelma Machisi, Tapiwa Shabani, Takunda Shabani   +5 more
doaj   +1 more source

Species diversity, primary productivity, and photosynthetic pathway in grasslands of eastern Pennsylvania

Ecosphere, 2023
We examined the relationship between primary productivity and diversity for grassland, meadow, and savanna (GMS) vegetation in northeastern Pennsylvania, USA, where the landscape is primarily forests, agriculture, and urban or suburban development.
Ned Fetcher, Jeffrey A. Stratford, Michael A. Steele, Kenneth M. Klemow   +3 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Social-ecological systems approach in drought-food insecurity nexus research

npj Sustainable Agriculture
Drought is increasingly seen as the next “pandemic,” threatening global populations and progress towards achieving zero hunger by 2030. Although drought and food security are well-researched, no studies synthesize the progress and gaps in drought-food ...
Debashis Roy, Yollanda Chepkoech Korir, Steven A. Gillespie, Md Sarwar Hossain   +3 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Impacts of solid waste management strategies in urban high density suburbs: a case of Amaveni suburb, Kwekwe, Zimbabwe

Discover Environment
Improper solid waste management is one of the causes of environmental and health problems in many cities worldwide. It is in this context that the study aimed to determine the solid waste management strategies used in Amaveni suburbs in Kwekwe, Zimbabwe ...
Chireshe Amato, Steven Jerie, Timothy Vurayayi Mutekwa, Tapiwa Shabani, Takunda Shabani, Muyambo Tafadzwa   +5 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source