Results 41 to 50 of about 234,590 (251)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Environmental Sustainability of Lighter Fluids
ACS OmegaLighter fluids are consumer products used only at a low-volume scale, representing a realizable goal of fossil fuel replacement by renewables. Physicochemical properties of four fossil-based conventional lighter fluids (Ronsonol, Zippo, Landmann, and Terracotta) and six selected biomass-based chemicals (γ-valerolactone, ethyl-levulinate, ethanol, n ...
Edit Cséfalvay, Viktória Kovács
openaire +3 more sources
Ecology and SocietyJust over ten years ago, resilience scholars proposed seven principles for enhancing the resilience of social-ecological systems. The authors argued that there was a pressing need for a better understanding of how the principles can be operationalized ...
Julia Baird +3 more
doaj +1 more source
Target proteins reprogrammed by As and As + Si treatments in Solanum lycopersicum L. fruit
BMC Plant Biology, 2017 Background Arsenic is an important contaminant of many arable soils worldwide, while silicon, one of the most abundant elements in the earth’s crust, interacts with As in the context of plant metabolism.
Marta Marmiroli +3 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Discover SustainabilityWildlife is an essential resource for ecosystem balance, yet natural and anthropogenic forces in Southern Africa threaten its conservation. Due to wildlife over-exploitation, fauna conservation is at an embryonic stage in Southern Africa, and achieving ...
Elvis Batsirai Gumbo +4 more
doaj +1 more source
Carboxypeptidase G and pterin deaminase metabolic pathways degrade folic acid in Variovorax sp. F1
BMC Microbiology, 2022 Background Folic acid (FA) is a synthetic vitamin (B9) and the oxidized form of a metabolic cofactor that is essential for life. Although the biosynthetic mechanisms of FA are established, its environmental degradation mechanism has not been fully ...
Yungmi You +5 more
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Discover Public HealthIndustrialisation and service provision expose involved people to occupational health risks, including solid waste workers. In Zimbabwe, many concerns focus on occupational health risks affecting workers in industries, giving little attention to those ...
Steven Jerie +4 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source