Results 61 to 70 of about 217,008 (251)

BASS - Biodiversity Assessments at Small Scales [PDF]

Research Ideas and Outcomes
Much of the work developed on biodiversity dynamics due to climate change focuses on large scales. Yet, we know that small scale is critical to fully understand biodiversity change, particularly for plants and small or less mobile organisms which might ...
Fernando Ascensão, Pedro Cardoso, Rui Rebelo, Mário Boieiro, Alice Nunes, Sergio Chozas, Inês do Rosário, Adriana Príncipe, Cristina Máguas, Cristina Branquinho, Paulo Borges   +10 more
doaj   +3 more sources

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

The potential role of safety, health, environmental quality (SHEQ) management systems in sustainable landfill management in Zimbabwe-a review

Discover Sustainability
Solid waste management is a demanding issue globally. Zimbabwe is among nations in Southern Africa that faces political and socio-economic challenges in solid waste management including landfill management. However, proper landfill management is critical
Steven Jerie, Tapiwa Shabani, Takunda Shabani, Amato Chireshe   +3 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Petroleum Hydrocarbon Contamination in Terrestrial Ecosystems—Fate and Microbial Responses

Molecules, 2019
Petroleum hydrocarbons represent the most frequent environmental contaminant. The introduction of petroleum hydrocarbons into a pristine environment immediately changes the nature of that environment, resulting in reduced ecosystem functionality. Natural
Adam Truskewycz, Taylor D. Gundry, Leadin S. Khudur, Adam Kolobaric, Mohamed Taha, Arturo Aburto-Medina, Andrew S. Ball, Esmaeil Shahsavari   +7 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Unmasking open market informality: merchandise and market interactions at Mtapa Open Market in Gweru, Zimbabwe

Discover Global Society
Open markets occupy a strategic position, providing products that customers need daily, despite being characterised by informality. There is a dearth of empirical research reporting explicitly on the confluence of merchandise characteristics and market ...
Juliet Chidochashe Runokunda, Mark Matsa, Beauty Dzawanda, Oshneck Mupepi   +3 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

The management of safety and health hazards associated with metal fabrication in Zimbabwe: a systematic review

Discover Public Health
Background In Zimbabwe, metal fabrication is an important industrial sector that makes a substantial contribution to employment and the country’s economy.
Steven Jerie, Thandekile Mirriam Mkosana, Tapiwa Shabani, Takunda Shabani   +3 more
doaj   +1 more source