Results 61 to 70 of about 1,485,059 (284)

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

open access: yesMolecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

OIDDE Learning Model Through Integrated Field Studies Abroad to Develop Ethnical Decision Skills of Candidate Biology Teachers: Indonesian Perspective [PDF]

open access: yes, 2017
This study aimed to describe the ethical problems, valuable experience, and ethical decision-making abilities about the environment by students through the application of OIDDE models on integrated field studies abroad.
Husamah, H.   +2 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Gall-Colonizing Ants and Their Role as Plant Defenders: From ‘Bad Job’ to ‘Useful Service’

open access: yesInsects, 2019
Galls are neoformed structures on host plant tissues caused by the attack of insects or other organisms. They support different communities of specialized parasitic insects (the gall inducers), and can also provide refuge to other insects, such as moths,
Daniele Giannetti   +4 more
doaj   +1 more source

The role of ICT in assuring environmental sustainability [PDF]

open access: yes, 2007
Information and Communication Technologies (ICT) affect the environment both positively and negatively at various levels. At the most direct level, production, use and disposal of IT equipment is becoming a serious environmental concern.
Volk, Olha Mykolaivna   +2 more
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Sustainability and international trade in resources [PDF]

open access: yes
This paper discusses environmental policies which aim at a sustainable use of domestic resources which are mobile. It assumes that one country introduces such a policy but the other country does not. If a resource is mobile, strict domestic environmental
Klepper, Gernot, Stähler, Frank
core  

Environmental, human health and socio-economic effects of cement powders: The multicriteria analysis as decisional methodology [PDF]

open access: yes, 2017
The attention to sustainability-related issues has grown fast in recent decades. The experience gained with these themes reveals the importance of considering this topic in the construction industry, which represents an important sector throughout the ...
Bellagamba, Simona   +2 more
core   +1 more source

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