Results 51 to 60 of about 588,114 (308)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Energy modeling and eco impact evaluation in direct metal laser sintering hybrid milling

Heliyon, 2020
This paper presents an analytical model of energy consumption for Direct metal laser sintering hybrid milling (DMLS-HM) additive manufacturing (AM) of stainless steel 316L.
Nabeel Ahmad, Emmanuel Ugo Enemuoh
doaj   +1 more source

The potential of additive manufacturing in the smart factory industrial 4.0: A review [PDF]

, 2019
Additive manufacturing (AM) or three-dimensional (3D) printing has introduced a novel production method in design, manufacturing, and distribution to end-users.
Dehghanghadikolaei, Amir, Emamian, Sattar S., Fotovvati, Behzad, Gisario, Annamaria, Mehrpouya, Mehrsha, Vosooghnia, Alireza   +5 more
core   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Some Interventions for Sustainability Leveraged Mechanical Engineering Education

EDUCATIO: Journal of Education
Embedding Sustainable Development Goals (SDGs) into engineering education is critical to prepare engineers who are both technically skilled and socially responsible.
Kapil Gupta, Shailendra Pawanr, Mfundo Nkosi   +2 more
doaj   +1 more source

Comparative life cycle assessment study for erosion control application with conventional shotcrete and geomat solutions [PDF]

E3S Web of Conferences
Geosynthetic products are used more frequently in civil and environmental engineering applications due to their technological, commercial, and sustainable advantages.
Ferrara M.L., Jayakrishnan P.V.
doaj   +1 more source

The Importance of Ecological and Spiritual Approaches in Chemical Engineering towards Practical Conception of Sustainable Development [PDF]

, 2011
The issues in sustainable development are of two kinds; the interdependent of three principle pillars of sustainable development-environment, social, and economy development and human spiritual development.
Azizan, Ramli, Mohd Shaiful Zaidi, Mat Desa   +1 more
core  

Engaging schools in the science of low-energy buildings [PDF]

, 2012
This article explores the relationship between the previous UK government’s initiative to rebuild and renew secondary schools, and the requirement for improved education for sustainable development in the UK.
Charnley, Fiona, Cook, Malcolm, Dowsett, Tony, Fleming, Margaret, Fleming, Paul, Mill, Greig   +5 more
core   +2 more sources

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source