Results 51 to 60 of about 584,647 (289)
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Some Interventions for Sustainability Leveraged Mechanical Engineering Education
EDUCATIO: Journal of EducationEmbedding Sustainable Development Goals (SDGs) into engineering education is critical to prepare engineers who are both technically skilled and socially responsible.
Kapil Gupta +2 more
doaj +1 more source
Mapping the sustainable development goals into the EDINSOST sustainability map of bachelor engineering degrees [PDF]
, 2019 © 2019 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes,creating new ...
Bragós Bardia, Ramon +6 more
core +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Comparative life cycle assessment study for erosion control application with conventional shotcrete and geomat solutions [PDF]
E3S Web of ConferencesGeosynthetic products are used more frequently in civil and environmental engineering applications due to their technological, commercial, and sustainable advantages.
Ferrara M.L., Jayakrishnan P.V.
doaj +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Energy modeling and eco impact evaluation in direct metal laser sintering hybrid milling
Heliyon, 2020 This paper presents an analytical model of energy consumption for Direct metal laser sintering hybrid milling (DMLS-HM) additive manufacturing (AM) of stainless steel 316L.
Nabeel Ahmad, Emmanuel Ugo Enemuoh
doaj +1 more source
Decision-making through sustainability [PDF]
, 2016 From immemorial time, dams have contributed significantly for the progress of civilizations. For this reason, nowadays, there is a vast engineering heritage.
Aguado de Cea, Antonio +1 more
core +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source