Results 61 to 70 of about 65,266 (258)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Phase Current Reconstruction of PMSG-Based Three-Phase PWM Rectifiers Using Linear Extended State Observer

Energies
As a core power supply component of the more electric aircraft (MEA), the reliability of the permanent magnet synchronous generator (PMSG) is of paramount importance.
Pengcheng Zhu, Sergio Vazquez, Eduardo Galvan, Ruifang Zhang, Juan M. Carrasco, Leopoldo G. Franquelo, Yongxiang Xu, Jiming Zou   +7 more
doaj   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Identifying sustainability assessment parameters for genetically engineered agrifoods

Plants, People, Planet
Societal Impact Statement A diverse portfolio of genetically engineered food crops, as well as animal livestock and fish, are currently being developed and commercialized.
Wei Wei, Khara Grieger, Christopher L. Cummings, Nick Loschin, Jennifer Kuzma   +4 more
doaj   +1 more source

Estimation of longitudinal dispersion co-efficient: A review

Cogent Engineering, 2016
Accurate determination of longitudinal dispersion coefficient in rivers or streams is necessary for pollution control and management. This can be achieved through tracer studies and has proven to be a reliable method for measuring pollution spread ...
Imokhai Theophilus Tenebe, Adebanji Samuel Ogbiye, David Olugbenga Omole, PraiseGod Chidozie Emenike   +3 more
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Classification of parameters affecting slip safety of limestones

Cogent Engineering, 2016
This study determines the appropriate surface processing techniques for limestone plates. slip resistance, which is required for the slip safety of pedestrians wearing shoes, is one of the most important parameters for the surface processing of limestone
G. Çoşkun, Gencay Sarıışık, A. Sarıışık   +2 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Enhanced global oil spill dataset from 1967 to 2023 based on text-form incident information

Scientific Data
s Knowing how much oil was released into the environment in each incident is critical to studying the environmental, ecological, and economic impacts of oil spills. However, the release amounts (RAs) for numerous oil spill incidents remain unavailable in
Yiming Liu, Zhuoli Yin, Hua Cai
doaj   +1 more source

Air quality perceptual index approach: Development and application with data from two Nigerian cities

Environmental and Sustainability Indicators
Due to the world's population growth, poor air quality (PAQ) has become a major health and environmental issue. Cities, in particular, have had to face the challenge of PAQ as a result of traffic and, in the case of the developing world, the use of ...
Timothy M. Chukwu, Stephen Morse, Richard J. Murphy   +2 more
doaj   +1 more source