Results 91 to 100 of about 18,458,137 (306)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Environmental values, knowledge and behaviour: Contributions of an emergent literature on the role of ethnicity and migration

, 2019
Amidst calls for paradigm shifts in environmental scholarship, we track an emergent literature on how environmental values, knowledge and behaviour (EVKB) change (or not) with the migration process.
L. Head, Natascha Klocker, I. Aguirre-Bielschowsky   +2 more
semanticscholar   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Do stakeholders’ values support transformative change in the food system? Evidence from the Netherlands

Sustainability: Science, Practice, & Policy
Research in the sustainability sciences often emphasizes values and value change as important drivers of sustainability transformations. Drawing from conceptualizations of values developed in environmental psychology and the environmental social sciences,
Adrian Rinscheid, Patrick Huntjens, Noelle Aarts   +2 more
doaj   +1 more source

In-kind conservation payments crowd in environmental values and increase support for government intervention: A randomized trial in Bolivia

, 2019
There is growing use of economic incentives such as Payments for Ecosystem Services (PES) to encourage sustainable land management. An important critique is that such approaches may unintentionally disrupt environmental and social values, ‘crowding out ...
Tara Grillos, P. Bottazzi, D. Crespo, N. Asquith, Julia P. G. Jones   +4 more
semanticscholar   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The role of carbon labels for consumer decisions: evidence from a class of Chinese students

Frontiers in Climate
Although achieving China's “3060” dual-carbon goals is an urgent priority, current research in the field of carbon labeling has paid limited attention to its pathways on consumers' green purchase decision.
Li Liu, Kaiqing Wang
doaj   +1 more source