Results 121 to 130 of about 1,052,465 (366)

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

open access: yesFEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani   +6 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

open access: yesFEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi   +6 more
wiley   +1 more source

Siyasal Ekoloji Çerçevesinde Devlet Kudretinin Yeşilleşmesine İlişkin Bir Tartışma

open access: yesTürk-Alman Üniversitesi Hukuk Fakültesi Dergisi
Bu çalışma kapsamında siyasal ekolojinin ideolojik temellerinden hareketle modern devlet iktidarının (Levitahan’ın) yeşilleşmesi incelenmiştir. Bu doğrultuda ekolojizm çerçevesinde tartışılan küresel çevresel değişimler, biyoçeşitlilik, iklim krizi ...
A. Aslı Şimşek Öner
doaj   +1 more source

Alluvial channel response to environmental perturbations: fill-terrace formation and sediment-signal disruption [PDF]

open access: gold, 2019
Stefanie Tofelde   +4 more
openalex   +1 more source

Environmental tracers

open access: yesEos, Transactions American Geophysical Union, 1991
Several naturally occurring tracers of water in natural systems (for example, stable isotopes of oxygen and hydrogen) are being widely used to determine the flow paths that water takes through a catchment. These chart the course of water from when it lands on the soil surface as rain or snow until it flows out of the catchment as streamflow. Tracing of
openaire   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

open access: yesFEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

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