Results 71 to 80 of about 1,052,465 (366)

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

MAKING THE GOOD EASY: THE SMART CODE ALTERNATIVE [PDF]

open access: yes, 2002
This article advocates for a new, fundamentally different plan for how cities should be coded, the Smart Code. It links urbanism and environmentalism and is strongly aligned with smart growth and sustainability.
Duany, Andres, Talen, Emily
core   +1 more source

Coming into the Anthropocene [PDF]

open access: yes, 2014
This essay reviews Professor Jonathan Cannon’s Environment in the Balance. Cannon’s book admirably analyzes the Supreme Court’s uptake of, or refusal of, the key commitments of the environmental-law revolution of the early 1970s.
Chey, Chan Oeurn   +6 more
core   +3 more sources

Screening for lung cancer: A systematic review of overdiagnosis and its implications

open access: yesMolecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz   +12 more
wiley   +1 more source

“We Need a Showing of All Hands”: Technological Utopianism in \u3cem\u3eMAKE\u3c/em\u3e Magazine [PDF]

open access: yes, 2011
Make magazine is a quarterly publication focused on do-it-yourself projects involving technology and innovation. The magazine also sponsors a biannual event, the Maker Faire, that brings “makers” together to share their knowledge.
Sivek, Susan Currie
core   +1 more source

Constructing a Social Problem: The Press and the Environment [PDF]

open access: yes, 1979
The U. S. daily press might seem to be in a strategic position to function as a claims-maker in the early construction of a social problem. But in the case of the manufacture of environmentalism as a social reality in the 1960\u27s and 70\u27s, the press
Griffin, Robert J.   +2 more
core   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Urban greening: environmentalism or marketable aesthetics

open access: yesAIMS Environmental Science, 2015
In recent decades, urban greening has been conceptualized, and subsequently marketed, as a way of making cities more sustainable. Urban greening has been actualized in large global cities, regional centers, and also in many cities in the Global South ...
Dominic Bowd   +2 more
doaj   +1 more source

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