Results 81 to 90 of about 4,695,098 (404)

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

open access: yesFEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

How do radical climate movements negotiate their environmental and their social agendas? A study of debates within the Camp for Climate Action (UK) [PDF]

open access: yes, 2011
This is a case study of the Camp for Climate Action, which has held several high-profile protest events in the UK since its inception in 2006. It analyses the Camp as a contested space where different emphases on environmental and social priorities have ...
Schlembach, Raphael
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

open access: yesMolecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz   +12 more
wiley   +1 more source

Urban greening: environmentalism or marketable aesthetics

open access: yesAIMS Environmental Science, 2015
In recent decades, urban greening has been conceptualized, and subsequently marketed, as a way of making cities more sustainable. Urban greening has been actualized in large global cities, regional centers, and also in many cities in the Global South ...
Dominic Bowd   +2 more
doaj   +1 more source

Revisiting the Role of Environmental Education in Eco-Friendly Awareness Formation

open access: yesРазвитие образования, 2020
The article is devoted to the analysis of the role that environmental education and upbringing play in the formation of eco-friendly awareness and thinking.
Ekaterina V. Petrova
doaj   +1 more source

Environmentalists' Behaviour and Environmental Policies policies [PDF]

open access: yes
In this partial equilibrium and static model, the impact of environmentalism on two countries' environmental policies is presented. First, the only (indirect) way environmentalists influence the choice of pollution taxes is through a negative term in the
Joan Canton
core  

Living Through The End of Nature: The Future of American Environmentalism by Paul Wapner [PDF]

open access: yes, 2014
Review of Living Through The End of Nature: The Future of American Environmentalism by Paul ...
Kraayenbrink, Taylor
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

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