Results 91 to 100 of about 11,563,248 (344)

Design Environments for Complex Systems [PDF]

, 2003
The paper describes an approach for modeling complex systems by hiding as much formal details as possible from the user, still allowing verification and simulation of the model.
Priami, Corrado
core  

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Single-electron transistors in electromagnetic environments

, 2004
The current-voltage (I-V) characteristics of single-electron transistors (SETs) have been measured in various electromagnetic environments. Some SETs were biased with one-dimensional arrays of dc superconducting quantum interference devices (SQUIDs). The
A. Amar, A.N. Cleland, D.B. Haviland, D.B. Haviland, D.B. Haviland, G. Schön, J.B. Kycia, L.J. Geerligs, M. Watanabe, M. Watanabe, M. Watanabe, M.T. Tuominen, Michio Watanabe, Y. Nakamura   +13 more
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Gerencia de entornos virtuales de aprendizaje en la gestión docente universitaria

Ecomatemático, 2018
The present research work has as a general objective to propose management training for the management of Virtual Learning Environments (EVA), aimed at teachers of the Department of Education, Humanities and Arts of the National Experimental ...
Carlos Alfredo Velasco Valderrama
doaj   +1 more source

Learning Through Rich Environments

, 2007
Research into games in education most frequently expresses itself in the form of noting that games interest and motivate, and that we might therefore find the learning process improved if we were to use games as a vehicle for the delivery of learning ...
Argles, David, Frazer, Alex, Wald, Mike, Wills, Gary   +3 more
core  

Learning in evolutionary environments [PDF]

, 1996
Not ...
Dosi, Giovanni, Fagiolo, Giorgio, Marengo, Luigi   +2 more
core   +2 more sources

Magnetic Reconnection in Extreme Astrophysical Environments

, 2011
Magnetic reconnection is a basic plasma process of dramatic rearrangement of magnetic topology, often leading to a violent release of magnetic energy. It is important in magnetic fusion and in space and solar physics --- areas that have so far provided ...
A. Bhattacharjee, A. Brandenburg, A. Burrows, A. Lazarian, A. Spitkovsky, A.A. Ballegooijen van, A.A. Galeev, A.I. MacFadyen, A.K. Harding, A.P. Goodson, A.R. Choudhuri, B. Paczynski, B. Warner, B.D. Farris, B.F. Liu, B.N. Rogers, C. Thompson, C. Thompson, C. Thompson, C. Thompson, C.A. Tout, C.H. Jaroschek, C.H. Jaroschek, C.H. Jaroschek, C.K. Li, C.R. D’Angelo, D. Biskamp, D. Giannios, D. Giannios, D. Giannios, D. Giannios, D. Giannios, D. Lynden-Bell, D. Proga, D.A. Larrabee, D.A. Uzdensky, D.A. Uzdensky, D.A. Uzdensky, D.A. Uzdensky, D.A. Uzdensky, D.A. Uzdensky, D.A. Uzdensky, D.A. Uzdensky, D.A. Uzdensky, D.A. Uzdensky, D.A. Uzdensky, D.A. Uzdensky, D.M. Palmer, Dmitri A. Uzdensky, E.D. Feigelson, E.G. Blackman, E.G. Zweibel, E.G. Zweibel, E.N. Parker, E.N. Parker, E.P. Mazets, F. Haardt, F. Heitsch, F.C. Michel, F.S. Mozer, F.V. Coroniti, G. Drenkhahn, H. Herold, H. Lesch, H.C. Spruit, H.E. Petschek, H.K. Lee, I. Contopoulos, J. Birn, J. Goodman, J. Pétri, J.G. Kirk, J.J. Aly, K. Shibata, L.S. Shepherd, M. Hesse, M. Lyutikov, M. Lyutikov, M. Lyutikov, M. Lyutikov, M. Lyutikov, M. Lyutikov, M. Lyutikov, M. Lyutikov, M. Umizaki, M. Yamada, M. Yamada, M. Øieroset, M.H.P.M. Putten van, M.H.P.M. Putten van, M.J. Rees, M.M. Romanova, M.M. Romanova, M.R. Hayashi, M.V. Medvedev, N. Bessho, N. Bessho, N. Vlahakis, N. Watanabe, N.F. Loureiro, P. Meszaros, P.A. Cassak, P.A. Cassak, P.A. Cassak, P.A. Cassak, P.A. Cassak, P.A. Sweet, P.M. Nilson, P.M. Woods, R. Samtaney, R. Schopper, R.G. Kleva, R.P. Drake, R.S. Steinolfson, S. Zenitani, S. Zenitani, S. Zenitani, S. Zenitani, S. Zenitani, S.E. Woosley, S.S. Komissarov, S.S. Komissarov, T. Matteo Di, T. Padmanabhan, T.D. Phan, V.L. Dorman, W. Daughton, W. Liu, Y. Huang, Y. Lyubarsky, Y. Masada, Y.E. Lyubarskii, Y.E. Lyubarsky, Y.E. Lyubarsky, Z.W. Ma   +134 more
core   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source