Results 151 to 160 of about 390,648 (313)
Drugs and brain mitochondrial enzymatic activities during post-natal development in rat
, 1976 The enzymatic activities of two mitochondrial enzymes, i.e. succinate dehydrogenase and NADH-cytochrome c reductase were investigated in the brain of rats at different stages of post-natal development.
BENZI, GIAN MARTINO +6 more
core
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Activation of enzymatic catalysis.
Indian journal of biochemistry & biophysics, 1999 Modulation of enzyme activity by inhibition and activation plays an important physiological role in regulation of cellular metabolism. Compared to the wealth of information available regarding inhibition of metabolic pathways, little is known about activation. Limited proteolysis of zymogens exemplifies irreversible activation.
K, Das-Panja +2 more
openaire +1 more source
Summary of cell growth and Aox enzymatic activities of the 27 kinase genes.
, 2016 Summary of cell growth and Aox enzymatic activities of the 27 kinase genes.
Xiangshan Zhou (837935) +8 more
core +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
, 2017 We developed activography to map enzymatic activities on tissue sections using activity-based probes.
G. Pampalakis +3 more
core +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Long-term effect of organic amendments on soil enzymatic activities.
, 2018 National audienceOrganic amendments are a valuable source of organic matter intended to increase agricultural soil quality. The use of long-term field experiments is very important to investigate the environmental impacts of recycling organic residues on
Grand, Cécile +6 more
core