Results 181 to 190 of about 681,027 (341)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Mechanistic coupling of enzymatic activities at the replisome. [PDF]

J Biol Chem
Welikala MU, Butterworth LJ, Beragama Arachchi RY, Trakselis MA.   +3 more
europepmc   +1 more source

Influence of resource-saving technologies of basic cultivation on the enzymatic activity of chernozem in the Krasnoyarsk forest-steppe

, 2018
Nikolay Vladimirovich Kozhevnikov, Alexandra Zaushintsena, Vasily Nikolaevich Romanov   +2 more
openalex   +2 more sources

Morphology, Carbohydrate Distribution, Gene Expression, and Enzymatic Activities Related to Cell Wall Hydrolysis in Four Barley Varieties during Simulated Malting [PDF]

, 2017
Natalie S. Betts, Laura G. Wilkinson, Shi F. Khor, Neil J. Shirley, Finn Lok, Birgitte Skadhauge, Rachel A. Burton, Geoffrey B. Fincher, Helen M. Collins   +8 more
openalex   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Extracellular enzymatic activities of octocorals and scleractinian corals under environmental stress. [PDF]

Sci Rep
Lange K, Blanckaert A, Marcus Do Noscimiento MI, Grover R, Fine M, Reynaud S, Ferrier-Pagès C.   +6 more
europepmc   +1 more source

Spatio-temporal variation in soil microbial biomass and enzymatic activity in different forest ecosystem of North-India

, 2016
Lovy Raj Chandra, Surabhi Gupta, Veena Pande, N. P. Singh   +3 more
openalex   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Recent Progress of Magnetic Nanomaterials with Enhanced Enzymatic Activities in Antitumor Therapy. [PDF]

Int J Mol Sci
Zhang Y, Li D, Liang H, Lan B, Chang P, Yang Y, Cheng Y, Li G, Lu H.   +8 more
europepmc   +1 more source

Isolation and Characterization of an RIP (Ribosome-Inactivating Protein)-Like Protein from Tobacco with Dual Enzymatic Activity

, 2004
Neelam Sharma, Sang‐Wook Park, Ramarao Vepachedu, Luigi Barbieri, Marialibera Ciani, Fiorenzo Stirpe, Brett J. Savary, Jorge M. Vivanco   +7 more
openalex   +1 more source