Results 181 to 190 of about 390,648 (313)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Potential of Subterranean Microbes: High-Throughput Screening for Industrially Relevant Enzymatic Activities in Dinaric Caves. [PDF]

Microbiologyopen
Babinskas J, Krutkevičius J, Lukić Bilela L, Bešta-Gajević R, Matijošytė I.   +4 more
europepmc   +1 more source

Enzymatic Activity of Polyalanyl Ribonuclease

Journal of Biological Chemistry, 1963
D, WELLNER, H L, SILMAN, M, SELA
openaire   +2 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Field scale responses of soil enzymatic activities and microbial indicators to combined bioinoculant-fertilizer management in mustard (Brassica juncea L.). [PDF]

Sci Rep
Singh RK, Soltane R, Baite NA, Mahajan NC, Mahto R, Vishwakarma DK, Aldosari FM, Alreshidi MA, Yadav KK, Abdulmonem WA.   +9 more
europepmc   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Class IIa HDACs Are Important Signal Transducers with Unclear Enzymatic Activities. [PDF]

Biomolecules
Brancolini C.
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Polypeptide encoded by the -1 PRF signal of SARS-CoV-2 controls multiple enzymatic activities of the viral NiRAN domain. [PDF]

NAR Mol Med
Hsu HT, Cho CP, Lin CL, Chang KY.
europepmc   +1 more source

Prior to versus after Metformin Treatment-Effects on Steroid Enzymatic Activities. [PDF]

Life (Basel), 2023
Gasser B, Escher G, Calin AE, Deppeler M, Marchon M, Mistry HD, Kurz J, Mohaupt MG.   +7 more
europepmc   +1 more source