Results 181 to 190 of about 665,401 (309)

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Establishment of neuronal and glial competence of neural stem cells requires distinct enzymatic activities of TET enzymes. [PDF]

Stem Cell Reports
Ebert BC, MacArthur IC, Ketchum HC, Musheev M, Niehrs C, Suzuki M, Dawlaty MM.   +6 more
europepmc   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Wounding causes rapid, intense upregulation of glycolytic and fermentative genes and enzymatic activities in harvested sugarbeet roots. [PDF]

Sci Rep
Fugate KK, Morin M, Eide JD, Lafta AM, Finger FL.   +4 more
europepmc   +1 more source

Identification of flexible Pif1-DNA interactions and their impacts on enzymatic activities. [PDF]

Nucleic Acids Res, 2022
Li J, Ma J, Kumar V, Fu H, Xu C, Wang S, Jia Q, Fan Q, Xi X, Li M, Liu H, Lu Y.   +11 more
europepmc   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

First genome sequence and functional profiling of <i>Psychrobacter</i> SC65A.3 preserved in 5,000-year-old cave ice: insights into ancient resistome, antimicrobial potential, and enzymatic activities. [PDF]

Front Microbiol
Paun VI, Itcus C, Lavin P, Chifiriuc MC, Purcarea C.   +4 more
europepmc   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

IDO Activation Affects BDNF/TrkB Signaling Pathway, Oxidative Stress, and Mitochondrial Enzymatic Activities in Temporal Lobe Epilepsy. [PDF]

Curr Issues Mol Biol
Xu J, Wei L, Fu J, Kong Z, Cai L.
europepmc   +1 more source

Response of microbiota to exogenous inoculation improved the enzymatic activities of medium-temperature Daqu. [PDF]

Front Microbiol, 2022
Pan Q, Huang J, Zhang S, Qin H, Wang X, Mu Y, Tang H, Zhou R.   +7 more
europepmc   +1 more source