Results 71 to 80 of about 691,475 (266)

Isolation of Native Fungi from Sawdust Collected at a Sawmill from Adeleke Area, Ogbomosho, Oyo State, Nigeria

Journal of Applied Sciences and Environmental Management
Sawdust is an agricultural waste and could be utilized in several productive and beneficial entities. Therefore, the objective of this paper is to assess the Isolation of Native Fungi from Sawdust collected at sawmill from Adeleke area, Ogbomosho, Oyo ...
A. P. Akomolafe, K. A. Odelade, S. O. Sulaimon   +2 more
doaj  

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Effect of mash enzyme and heat treatments on the cellular antioxidant activity of black currant (Ribes nigrum), raspberry (Rubus idaeus), and blueberry (Vaccinium myrtillus) juices

CyTA - Journal of Food, 2017
The aim of this study was to determine the effect of mash enzymatic maceration and heating treatments before pressing on the antioxidant activities in selected berry juices.
Cecilia Bender, Karina V. Killermann, Dirk Rehmann, Helmut H. Weidlich   +3 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Studi perbandingan metode oksidasi enzimatis terhadap aktivitas antioksidan ekstrak air teh kratom (Mitragyna speciosa Korth.)

Agrointek
One of the kratom (Mitragyna speciosa Korth.) products in Kapuas Hulu is fermented kratom tea powder, produced by the enzymatic oxidation process, which is very different from the processing of black tea.
Brigita Ratna Harsanti, Sulvi Purwayantie, Dzul Fadly   +2 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Allosteric regulation of deubiquitylase activity through ubiquitination

Frontiers in Molecular Biosciences, 2015
Ataxin-3, the protein responsible for spinocerebellar ataxia type-3, is a cysteine protease that specifically cleaves poly-ubiquitin chains and participates in the ubiquitin proteasome pathway.
Serena eFaggiano, Rajesh P. Menon, Geoff P. Kelly, Sokol V. Todi, K. Matthew Scaglione, Petr V. Konarev, Petr V. Konarev, Dmitri I. Svergun, Henry L. Paulson, Annalisa ePastore   +9 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Enzymatic and mRNA Transcript Response of Ovine 6-Phosphogluconate Dehydrogenase (6PGD) in Respect to Different Milk Yield

Biochemistry Research International, 2010
Ovine 6-phosphogluconate dehydrogenase (6PGD) is an enzyme of the pentose phosphate pathway, providing the necessary compounds of NADPH for the synthesis of fatty acids.
Stamatina Trivizaki, George P. Laliotis, Iosif Bizelis, Maria A. Charismiadou, Emmanuel Rogdakis   +4 more
doaj   +1 more source