Results 91 to 100 of about 898,805 (244)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Optimization of Enzymatic Gas-Phase Reactions by Increasing the Long-Term Stability of the Catalyst [PDF]

, 2004
Enzymatic gas-phase reactions are usually performed in continuous reactors, and thus very stable and active catalysts are required to perform such transformations on cost-effective levels.
Ferloni, Clara,, Daussmann, Thomas,, Hummel, Werner, Clara Ferloni, Büchs, Jochen, Werner Hummel, Heinemann, Matthias, Matthias Heinemann, Daußmann, Thomas, Heinemann, Matthias,, Büchs, Jochen,, Heinemann, Matthias; id_orcid, Jochen Bu Chs, Ferloni, Clara, Thomas Daussmann, Hummel, Werner,   +15 more
core   +2 more sources

DEVELOPMENT OF A GOLD NANOPARTICLE BASED ELECTROCHEMICAL BIOSENSOR FOR DETECTION OF PHENOLIC COMPOUNDS

Journal of the Turkish Chemical Society Section B: Chemical Engineering, 2017
In this study, an enzymatic biosensor was developed with gold nanoparticles and its performance was tested for detection of phenolic compounds. Glassy carbon working electrode (GCE) was covered with different combinations of chitosan (Chit) as a support,
İlker Polatoglu, Melike Kızılkaya, Ülfet Eren   +2 more
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Screening and mechanistic evaluation of antioxidants for mitigating beany flavor formation during pea protein isolation

Current Research in Food Science
This study investigated the role of lipid oxidation in off-flavor development during pea protein (PP) extraction via alkaline solubilization and isoelectric precipitation and its mitigation through antioxidant treatment. Four antioxidants (coffee extract,
José Villacís-Chiriboga, Elahe Sharifi, Madeleine Jönsson, Karin Wendin, Mehdi Abdollahi   +4 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

The economic and statistical value of forecast combinations under regime switching: an application to predictable U.S. returns [PDF]

We address one interesting case — the predictability of excess US asset returns from macroeconomic factors within a flexible regime switching VAR framework — in which the presence of regimes may lead to superior forecasting performance from forecast ...
Massimo Guidolin, Carrie Fangzhou Na
core  

Continuous enzymatic interesterification of lard and soybean oil blend: Effects of different flow rates on physical properties and acyl migration

, 2012
Continuous enzymatic interesterification is an alternative to chemical interesterification for lipid modification technology which is economically viable for large scale use.
Silva, Roberta Claro da, Capacla, Isabele Renata, Isabele Renata Capacla, Luiz Antonio Gioielli, Marcia Hazzan, Hazzan, Márcia, Fabiana Andreia Schaffer De Martini Soares, Maria Inês Almeida Gonçalves, Almeida Goncalves, Maria Ines, Schaffer de Martini Soares, Fabiana Andreia, Gioielli, Luiz Antonio, Roberta Claro da Silva   +11 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source