Results 101 to 110 of about 898,805 (244)

Enzymatic production of Volatile Organosulphur Compounds for the Flavour and Fragrance Industry [PDF]

, 2013
Volatile organosulphur compounds (VOSC) are a diverse group of chemical entities, which are among the highest impact aroma chemicals (HIACs) in the flavour and fragrance (F&F) industry.
JAMES, AGATA,BARBARA
core  

Influence of pectoinuline and its combinations with taurine on detoxic activity of liver

RUDN Journal of Medicine, 2012
Influence of pectoinuline, received by various methods from tubers of Jerusalem artichoke, and its combinations with taurine on liver's detoxic activity according to hepatotoxic and leads-ions egestion (Pb2+) level have been studied It was established ...
J K Vasilenko, M T Kisieva, N S Zyablitseva, V A Kompantsev, A L Belousova   +4 more
doaj  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Hypoglycemic activity of pectoinuline with taurine

RUDN Journal of Medicine, 2011
Influence of Pectoinuline, received by aqueous-enzymatic method from tubers of Jerusalem artichoke, and its combinations with Taurine on blood glucose level in animals after administration course and animals with alloxan diabetes was investigated ...
N S Zyablitseva, V A Kompantsev, M T Kisieva, A L Belousova, Yu K Vasilenko   +4 more
doaj  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Enzymatic synthesis of surfactants based on polyethylene glycol and stearic or 12-hydroxystearic acid

, 2004
High-purity mono- and di-esters of polyethylene glycol (molecular weight: 600) with stearic acid or 12-hydroxystearic acid was afforded using enzymatic catalysis with immobilized Candida antarctica lipase B.
Viklund, Fredrik,, Hult, Karl,
core   +1 more source

Development and evaluation of a rapid enzymatic hydrolysis test method to assess the biodegradability of organic waste [PDF]

, 2008
The amount of biodegradable municipal waste (BMW) that can be disposed of in a landfill must be reduced, in accordance with the landfill allowance trading scheme (LATS) in England and Scotland (LAS in Wales).
Wagland, Stuart T.
core   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source