Results 251 to 260 of about 821,766 (339)

Synthetic Lethal Therapy Based on Dimorphism for Systemic Infection of Drug‐Resistant Candida albicans

Advanced Science, EarlyView.
To tackle the alarming mortality rate linked to Candida albicans infections, a synthetic lethal strategy precisely aimed at the two distinct forms of this fungus: yeast and hyphae is formulated. Ultimately, through the innovative use of macrophage membranes for drug delivery, the effectiveness of this strategy is substantially boosted while ...
Yang Gao, Jiahe Su, Jiawei Yuan, Qinyan Cao, Yue Wu, Yuyang Xiao, Guang Yang, Ruomu Xia, Jingpeng Yang, Yanan Li, Lina Wu, He Huang, Lingtong Meng   +12 more
wiley   +1 more source

Producing mixed linked xylooligosaccharides from red algae biomass through single-step enzymatic hydrolysis. [PDF]

Biotechnol Biofuels Bioprod
Teune M, Suster C, Wolf Y, Michels N, Mieth H, Döhler T, Bartosik D, Krull J, Hehemann JH, Schweder T, Stanetty C, Bornscheuer UT.   +11 more
europepmc   +1 more source

ENZYMATIC HYDROLYSIS OF GLYCOGEN

Journal of Biological Chemistry, 1929
openaire   +1 more source

Enzymatic Hydrolysis of Cellulose [PDF]

, 2010
openaire   +1 more source

Surface Engineered Biomolecular Condensates for Targeted Cell Cytotoxicity

Advanced Science, EarlyView.
Interfacial engineering of biomolecular condensates with a decanoic acid (DA) membrane enables molecular‐weight‐gated enzyme localization. Small biomolecules (≤60 kDa) enrich internally, while high‐molecular‐weight alkaline phosphatase (ALP) localizes at the interface.
Chengying Yin, Cheng Wu, Xinran Yu, Yifeng Zhu, Baohu Wu, Yue Wang, Liangfei Tian   +6 more
wiley   +1 more source

Ultrasound-assisted enzymatic hydrolysis of loach (Misgurnus anguillicaudatus) protein for antioxidant peptides: process optimization, structural characterization, and Keap1/Nrf2-mediated antioxidant mechanism. [PDF]

Ultrason Sonochem
Chu Z, Qu G, Yang F, Hu Z, Luo F, Lin Q.
europepmc   +1 more source

AI‐Based D‐Amino Acid Substitution for Optimizing Antimicrobial Peptides to Treat Multidrug‐Resistant Bacterial Infection

Advanced Science, EarlyView.
This study constructed the first D‐amino acid antimicrobial peptide dataset and developed an AI model for efficient screening of substitution sites, with 80% of candidate peptides showing enhanced activity. The lead peptide dR2‐1 demonstrated potent antimicrobial activity in vitro and in vivo, high stability, and low toxicity.
Yinuo Zhao, Qingzhou Kong, Haifan Gong, Lixiang Li, Jialu Fu, Boyao Wan, Peizhu Wang, Xiaojuan Li, Yue Wang, Jinghui Zhang, Yanbo Yu, Xiaoyun Yang, Xiuli Zuo, Haina Wang, Yanqing Li   +14 more
wiley   +1 more source

Valorization of aquaculture side streams from sea bream and sea bass by enzymatic hydrolysis and fractionation: chemical and biological insights. [PDF]

Front Nutr
Jenssen M, Sone I, Grasso F, Turrini F, Tardanico F, Atanasio GN, Paz DM, Sobrado RV, Martínez MA, Boggia R, Grasselli E, Lian K.   +11 more
europepmc   +1 more source

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source